Abstract
Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, ENIGMA, to identify reliable neural correlates of major depressive disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work by precisely mapping localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus. Harmonized data processing and statistical analyses were conducted locally at each site, and findings were aggregated by meta-analysis. Relative to CTL, patients with adolescent-onset MDD (≤ 21 years) had lower thickness and surface area of the subiculum, cornu ammonis (CA) 1 of the hippocampus and basolateral amygdala (Cohen's d = −0.164 to −0.180). Relative to first-episode MDD, recurrent MDD patients had lower thickness and surface area in the CA1 of the hippocampus and the basolateral amygdala (Cohen's d = −0.173 to −0.184). Our results suggest that previously reported MDD-associated volumetric differences may be localized to specific subfields of these structures that have been shown to be sensitive to the effects of stress, with important implications for mapping treatments to patients based on specific neural targets and key clinical features.
Original language | English |
---|---|
Pages (from-to) | 341-351 |
Number of pages | 11 |
Journal | Human Brain Mapping |
Volume | 43 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2022 |
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
Subcortical shape alterations in major depressive disorder : Findings from the ENIGMA major depressive disorder working group. / Ho, Tiffany C.; Gutman, Boris; Pozzi, Elena et al.
In: Human Brain Mapping, Vol. 43, No. 1, 01.2022, p. 341-351.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Subcortical shape alterations in major depressive disorder
T2 - Findings from the ENIGMA major depressive disorder working group
AU - Ho, Tiffany C.
AU - Gutman, Boris
AU - Pozzi, Elena
AU - Grabe, Hans J.
AU - Hosten, Norbert
AU - Wittfeld, Katharina
AU - Völzke, Henry
AU - Baune, Bernhard
AU - Dannlowski, Udo
AU - Förster, Katharina
AU - Grotegerd, Dominik
AU - Redlich, Ronny
AU - Jansen, Andreas
AU - Kircher, Tilo
AU - Krug, Axel
AU - Meinert, Susanne
AU - Nenadic, Igor
AU - Opel, Nils
AU - Dinga, Richard
AU - Veltman, Dick J.
AU - Schnell, Knut
AU - Veer, Ilya
AU - Walter, Henrik
AU - Gotlib, Ian H.
AU - Sacchet, Matthew D.
AU - Aleman, André
AU - Groenewold, Nynke A.
AU - Stein, Dan J.
AU - Li, Meng
AU - Walter, Martin
AU - Ching, Christopher R.K.
AU - Jahanshad, Neda
AU - Ragothaman, Anjanibhargavi
AU - Isaev, Dmitry
AU - Zavaliangos-Petropulu, Artemis
AU - Thompson, Paul M.
AU - Sämann, Philipp G.
AU - Schmaal, Lianne
N1 - Funding Information: This work was supported by NIH grants U54 EB020403 and R01 MH116147 to P. M. T. The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net (CMR) (http://www.medizin.uni-greifswald.de/icm) of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. The FOR2107 cohort was supported by the German Research Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to U. D.; SFB-TRR58, Projects C09 and Z02 to U. D.; grant FOR2107 KR 3822/7-2 to A. K.; FOR2107 KI 588/14-2 to T. K., FOR2107 NE 2254/1-2 to I. N., and FOR2107 JA 1890/7-2 to A. J.), the Interdisciplinary Center for Clinical Research (IZKF) of the Medical Faculty of Münster (grant Dan3/012/17 to U. D.). DIP-Groningen cohort was supported by the Gratama Foundation, the Netherlands (2012/35 to N. G.). The CODE cohort was collected from studies funded by Lundbeck and the German Research Foundation (WA 1539/4-1, SCHN 1205/3-1, SCHR443/11-1). The Magdeburg-Sexpect cohort was supported by the German Research Foundation (DFG-SFB779/TPA06). L. S. is supported by a NHMRC Career Development Fellowship (1140764). T. C. H. is supported in part by NIH grant K01 MH117442. N. J. is supported by NIH grants R01 MH117601, R01 AG059874, and U54 EB020403. P. M. T. is supported in part by NIH grants U54 EB020403, R01 MH116147, R56 AG058854, R01 MH111671 and P41 EB015922. C. R. K. C. is supported in part by T32 AG058507, T32 MH073526, and U54 EB02403. H. J. G. is supported in part by the German Research Foundation (DFG), the German Ministry of Education and Research (BMBF), the DAMP Foundation, Fresenius Medical Care, the EU Joint Programme Neurodegenerative Disorders (JPND), and the European Social Fund (ESF). I. H. G. is supported in part by NIH grant R37 MH101495. P. G. S. is supported in part by the German Research Foundation (DFG, SA 1358/2-1) and the Max Planck Institute of Psychiatry, Munich. H. J. G. has received travel grants and speakers honoraria from Fresenius Medical Care and Janssen Cilag. K. S. has consulted for Roche Pharmaceuticals and Servier Pharmaceuticals. P. M. T. and C. R. K. C. have received partial research support from Biogen, Inc. unrelated to the topic of this manuscript. All other authors declare no biomedical conflicts of interest. The funding agencies played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Funding Information: L. S. is supported by a NHMRC Career Development Fellowship (1140764). T. C. H. is supported in part by NIH grant K01 MH117442. N. J. is supported by NIH grants R01 MH117601, R01 AG059874, and U54 EB020403. P. M. T. is supported in part by NIH grants U54 EB020403, R01 MH116147, R56 AG058854, R01 MH111671 and P41 EB015922. C. R. K. C. is supported in part by T32 AG058507, T32 MH073526, and U54 EB02403. H. J. G. is supported in part by the German Research Foundation (DFG), the German Ministry of Education and Research (BMBF), the DAMP Foundation, Fresenius Medical Care, the EU Joint Programme Neurodegenerative Disorders (JPND), and the European Social Fund (ESF). I. H. G. is supported in part by NIH grant R37 MH101495. P. G. S. is supported in part by the German Research Foundation (DFG, SA 1358/2‐1) and the Max Planck Institute of Psychiatry, Munich. Funding Information: The CODE cohort was collected from studies funded by Lundbeck and the German Research Foundation (WA 1539/4‐1, SCHN 1205/3‐1, SCHR443/11‐1). Funding Information: The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net (CMR) ( http://www.medizin.uni-greifswald.de/icm ) of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg‐West Pomerania. MRI scans in SHIP and SHIP‐TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg‐West Pomerania. Funding Information: The Magdeburg‐Sexpect cohort was supported by the German Research Foundation (DFG‐SFB779/TPA06). Funding Information: The FOR2107 cohort was supported by the German Research Foundation (DFG, grant FOR2107 DA1151/5‐1 and DA1151/5‐2 to U. D.; SFB‐TRR58, Projects C09 and Z02 to U. D.; grant FOR2107 KR 3822/7‐2 to A. K.; FOR2107 KI 588/14‐2 to T. K., FOR2107 NE 2254/1‐2 to I. N., and FOR2107 JA 1890/7‐2 to A. J.), the Interdisciplinary Center for Clinical Research (IZKF) of the Medical Faculty of Münster (grant Dan3/012/17 to U. D.). Funding Information: National Health and Medical Research Council, Grant/Award Number: 1140764; National Institute of Aging, Grant/Award Numbers: R01AG059874, R56AG058854, T32AG058507; National Institute of Biomedical Imaging and Bioengineering, Grant/Award Numbers: P41EB015922, U54EB020403; National Institute of Mental Health, Grant/Award Numbers: K01MH117442, R01MH117601, R01MH111671, R01MH116147, T32MH073526, R37MH101495; Biogen, Inc.; Roche Pharmaceuticals and Servier Pharmaceuticals; Fresenius Medical Care and Janssen Cilag; Max Planck Institute of Psychiatry, Munich; European Social Fund (ESF); EU Joint Programme Neurodegenerative Disorders (JPND); Fresenius Medical Care; DAMP Foundation; German Ministry of Education and Research (BMBF); Lundbeck; Gratama Foundation, Grant/Award Number: 2012/35; Interdisciplinary Center for Clinical Research (IZKF) of the Medical Faculty of Münster, Grant/Award Number: Dan3/012/17; German Research Foundation, Grant/Award Numbers: SA 1358/2‐1, DFG‐SFB779/TPA06, SCHR443/11‐1, SCHN 1205/3‐1, WA 1539/4‐1, FOR2107 JA 1890/7‐2, FOR2107 NE 2254/1‐2, FOR2107 KI 588/14‐2, FOR2107 KR 3822/7‐2, SFB‐TRR58, DA1151/5‐2, FOR2107 DA1151/5‐1; Federal State of Mecklenburg‐West Pomerania; Siemens Healthineers; German Federal State of Mecklenburg‐West Pomerania Funding information Publisher Copyright: © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
PY - 2022/1
Y1 - 2022/1
N2 - Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, ENIGMA, to identify reliable neural correlates of major depressive disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work by precisely mapping localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus. Harmonized data processing and statistical analyses were conducted locally at each site, and findings were aggregated by meta-analysis. Relative to CTL, patients with adolescent-onset MDD (≤ 21 years) had lower thickness and surface area of the subiculum, cornu ammonis (CA) 1 of the hippocampus and basolateral amygdala (Cohen's d = −0.164 to −0.180). Relative to first-episode MDD, recurrent MDD patients had lower thickness and surface area in the CA1 of the hippocampus and the basolateral amygdala (Cohen's d = −0.173 to −0.184). Our results suggest that previously reported MDD-associated volumetric differences may be localized to specific subfields of these structures that have been shown to be sensitive to the effects of stress, with important implications for mapping treatments to patients based on specific neural targets and key clinical features.
AB - Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, ENIGMA, to identify reliable neural correlates of major depressive disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work by precisely mapping localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus. Harmonized data processing and statistical analyses were conducted locally at each site, and findings were aggregated by meta-analysis. Relative to CTL, patients with adolescent-onset MDD (≤ 21 years) had lower thickness and surface area of the subiculum, cornu ammonis (CA) 1 of the hippocampus and basolateral amygdala (Cohen's d = −0.164 to −0.180). Relative to first-episode MDD, recurrent MDD patients had lower thickness and surface area in the CA1 of the hippocampus and the basolateral amygdala (Cohen's d = −0.173 to −0.184). Our results suggest that previously reported MDD-associated volumetric differences may be localized to specific subfields of these structures that have been shown to be sensitive to the effects of stress, with important implications for mapping treatments to patients based on specific neural targets and key clinical features.
KW - amygdala
KW - ENIGMA
KW - hippocampus
KW - major depressive disorder (MDD)
KW - nucleus accumbens
KW - shape analysis
UR - http://www.scopus.com/inward/record.url?scp=85082082567&partnerID=8YFLogxK
U2 - 10.1002/hbm.24988
DO - 10.1002/hbm.24988
M3 - Article
C2 - 32198905
AN - SCOPUS:85082082567
VL - 43
SP - 341
EP - 351
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 1
ER -