TY - JOUR
T1 - Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia
AU - Slot, Rosalinde E.R.
AU - Sikkes, Sietske A.M.
AU - Berkhof, Johannes
AU - Brodaty, Henry
AU - Buckley, Rachel
AU - Cavedo, Enrica
AU - Dardiotis, Efthimios
AU - Guillo-Benarous, Francoise
AU - Hampel, Harald
AU - Kochan, Nicole A.
AU - Lista, Simone
AU - Luck, Tobias
AU - Maruff, Paul
AU - Molinuevo, José Luis
AU - Kornhuber, Johannes
AU - Reisberg, Barry
AU - Riedel-Heller, Steffi G.
AU - Risacher, Shannon L.
AU - Roehr, Susanne
AU - Sachdev, Perminder S.
AU - Scarmeas, Nikolaos
AU - Scheltens, Philip
AU - Shulman, Melanie B.
AU - Saykin, Andrew J.
AU - Verfaillie, Sander C.J.
AU - Visser, Pieter Jelle
AU - Vos, Stephanie J.B.
AU - Wagner, Michael
AU - Wolfsgruber, Steffen
AU - Jessen, Frank
AU - Boada, Mercè
AU - de Deyn, Peter Paul
AU - Jones, Roy
AU - Frisoni, Giovanni
AU - Spiru, Luiza
AU - Nobili, Flavio
AU - Freund-Levi, Yvonne
AU - Soininen, Hilkka
AU - Verhey, Frans
AU - Wallin, Åsa K.
AU - Touchon, Jacques
AU - Rikkert, Marcel Olde
AU - Rigaud, Anne Sophie
AU - Bullock, Roger
AU - Tsolaki, Magda
AU - Vellas, Bruno
AU - Wilcock, Gordon
AU - Froelich, Lutz
AU - Bakardjian, Hovagim
AU - Benali, Habib
AU - Vergallo, Andrea
AU - Younsi, Nadjia
AU - Alzheimer's Disease Neuroimaging Initiative
AU - DESCRIPA working group
AU - INSIGHT-preAD study group
AU - SCD-I working group
AU - van der Flier, WM
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.
AB - Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.
KW - Alzheimer's disease
KW - Dementia incidence
KW - Dementia Lewy bodies
KW - Frontotemporal dementia
KW - Preclinical Alzheimer's disease
KW - Subjective cognitive decline
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=85056582914&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2018.10.003
DO - 10.1016/j.jalz.2018.10.003
M3 - Article
C2 - 30555032
AN - SCOPUS:85056582914
VL - 15
SP - 465
EP - 476
JO - Alzheimers & Dementia
JF - Alzheimers & Dementia
SN - 1552-5260
IS - 3
ER -