Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Rosalinde E.R. Slot, Sietske A.M. Sikkes, Johannes Berkhof, Henry Brodaty, Rachel Buckley, Enrica Cavedo, Efthimios Dardiotis, Francoise Guillo-Benarous, Harald Hampel, Nicole A. Kochan, Simone Lista, Tobias Luck, Paul Maruff, José Luis Molinuevo, Johannes Kornhuber, Barry Reisberg, Steffi G. Riedel-Heller, Shannon L. Risacher, Susanne Roehr, Perminder S. SachdevNikolaos Scarmeas, Philip Scheltens, Melanie B. Shulman, Andrew J. Saykin, Sander C.J. Verfaillie, Pieter Jelle Visser, Stephanie J.B. Vos, Michael Wagner, Steffen Wolfsgruber, Frank Jessen, Hovagim Bakardjian, Habib Benali, Andrea Vergallo, Nadjia Younsi, Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group, SCD-I working group, WM van der Flier

Research output: Contribution to journalArticleAcademicpeer-review


Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.

Original languageEnglish
Pages (from-to)465-476
Number of pages12
JournalAlzheimer's and Dementia
Issue number3
Publication statusPublished - 1 Mar 2019

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