Substrate recognition by vitamin K-dependent carboxylase

M. M W Ulrich, B. A M Soute, L. J M Van Haarlem, C. Vermeer

Research output: Contribution to journalArticleAcademicpeer-review


Decarboxylated osteocalcins were prepared and purified from bovine, chicken, human and monkey bones and assayed for their ability to serve as a substrate for vitamin K-dependent carboxylase from bovine liver. Substantial differences were observed, especially between bovine and monkey d-osteocalcin. Since these substrates differ only in their amino acid residues 3 and 4, it seems that these residues play a role in the recognition of a substrate by hepatic carboxylase.

Original languageEnglish
Pages (from-to)17-19
Number of pages3
JournalThrombosis and Haemostasis
Issue number1
Publication statusPublished - 1 Dec 1987

Cite this