89Zr-labeled compounds for PET imaging guided personalized therapy

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

89Zr-immuno-PET is an attractive option for the in vivo evaluation of monoclonal antibodies (mAbs). For the coupling of 89Zr to monoclonal antibodies several conjugation strategies are available all using desferrioxamine as chelate. Here we discuss the production of 89Zr, the available methods for coupling of 89Zr via desferrioxamine to mAbs, and the evaluation of 89Zr-mAb conjugates in preclinical and clinical studies.

Original languageEnglish
JournalDrug Discovery Today: Technologies
Volume8
Issue number2-4
DOIs
Publication statusPublished - 1 Jan 2011

Cite this

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title = "89Zr-labeled compounds for PET imaging guided personalized therapy",
abstract = "89Zr-immuno-PET is an attractive option for the in vivo evaluation of monoclonal antibodies (mAbs). For the coupling of 89Zr to monoclonal antibodies several conjugation strategies are available all using desferrioxamine as chelate. Here we discuss the production of 89Zr, the available methods for coupling of 89Zr via desferrioxamine to mAbs, and the evaluation of 89Zr-mAb conjugates in preclinical and clinical studies.",
author = "Vugts, {Danielle J.} and {Van Dongen}, {Guus A.M.S.}",
year = "2011",
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language = "English",
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journal = "Drug Discovery Today: Technologies",
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89Zr-labeled compounds for PET imaging guided personalized therapy. / Vugts, Danielle J.; Van Dongen, Guus A.M.S.

In: Drug Discovery Today: Technologies, Vol. 8, No. 2-4, 01.01.2011.

Research output: Contribution to journalReview articleAcademicpeer-review

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AU - Van Dongen, Guus A.M.S.

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AB - 89Zr-immuno-PET is an attractive option for the in vivo evaluation of monoclonal antibodies (mAbs). For the coupling of 89Zr to monoclonal antibodies several conjugation strategies are available all using desferrioxamine as chelate. Here we discuss the production of 89Zr, the available methods for coupling of 89Zr via desferrioxamine to mAbs, and the evaluation of 89Zr-mAb conjugates in preclinical and clinical studies.

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SN - 1740-6749

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