89Zr-labeled compounds for PET imaging guided personalized therapy

Danielle J. Vugts*, Guus A.M.S. Van Dongen

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

89Zr-immuno-PET is an attractive option for the in vivo evaluation of monoclonal antibodies (mAbs). For the coupling of 89Zr to monoclonal antibodies several conjugation strategies are available all using desferrioxamine as chelate. Here we discuss the production of 89Zr, the available methods for coupling of 89Zr via desferrioxamine to mAbs, and the evaluation of 89Zr-mAb conjugates in preclinical and clinical studies.

Original languageEnglish
JournalDrug Discovery Today: Technologies
Volume8
Issue number2-4
DOIs
Publication statusPublished - 1 Jan 2011

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