TY - JOUR
T1 - Supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink enhances postprandial muscle protein synthesis and muscle mass in healthy older men
AU - Chanet, Audrey
AU - Verlaan, Sjors
AU - Salles, Jérôme
AU - Giraudet, Christophe
AU - Patrac, Véronique
AU - Pidou, Véronique
AU - Pouyet, Corinne
AU - Hafnaoui, Nordine
AU - Blot, Adeline
AU - Cano, Noël
AU - Farigon, Nicolas
AU - Bongers, Anke
AU - Jourdan, Marion
AU - Luiking, Yvette
AU - Walrand, Stéphane
AU - Boirie, Yves
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background: A promising strategy to help older adults preserve or build muscle mass is to optimize muscle anabolism through providing an adequate amount of high-quality protein at each meal. Objective: This ''proof of principle'' study investigated the acute effect of supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink on postprandial muscle protein synthesis and longer-term effect on muscle mass in healthy older adults. Methods: A randomized, placebo-controlled, double-blind study was conducted in 24 healthy older men [mean ± SD: age 71± 4 y; body mass index (in kg/m2) 24.762.8] between September 2012 and October 2013 at the Unit of Human Nutrition, University of Auvergne, Clermont-Ferrand, France. Participants received a medical nutrition drink [test group; 21 g leucineenriched whey protein, 9 g carbohydrates, 3 g fat, 800 IU cholecalciferol (vitamin D3), and 628 kJ] or a noncaloric placebo (control group) before breakfast for 6wk.Mixedmuscle protein fractional synthesis rate (FSR)wasmeasured atweek 0 in the basal and postprandial state, after study product intake with a standardized breakfast with the use of L-[2H5]-phenylalanine tracer methodology. The longer-term effect of the medical nutrition drink was evaluated by measurement of appendicular lean mass, representing skeletal muscle mass at weeks 0 and 6, by dual-energy X-ray absorptiometry. Results: Postprandial FSR (0-240 min) was higher in the test group than in the control group [estimate of difference (ED): 0.022%/h; 95% CI: 0.010%/h, 0.035%/h; ANCOVA, P = 0.001]. The test group gained more appendicular lean mass than the control group after 6 wk (ED: 0.37 kg; 95% CI: 0.03, 0.72 kg; ANCOVA, P = 0.035), predominantly as leg lean mass (ED: 0.30 kg; 95% CI: 0.03, 0.57 kg; ANCOVA, P = 0.034). Conclusions: Supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink stimulated postprandial muscle protein synthesis and increased muscle mass after 6 wk of intervention in healthy older adults and may therefore be a way to support muscle preservation in older people.
AB - Background: A promising strategy to help older adults preserve or build muscle mass is to optimize muscle anabolism through providing an adequate amount of high-quality protein at each meal. Objective: This ''proof of principle'' study investigated the acute effect of supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink on postprandial muscle protein synthesis and longer-term effect on muscle mass in healthy older adults. Methods: A randomized, placebo-controlled, double-blind study was conducted in 24 healthy older men [mean ± SD: age 71± 4 y; body mass index (in kg/m2) 24.762.8] between September 2012 and October 2013 at the Unit of Human Nutrition, University of Auvergne, Clermont-Ferrand, France. Participants received a medical nutrition drink [test group; 21 g leucineenriched whey protein, 9 g carbohydrates, 3 g fat, 800 IU cholecalciferol (vitamin D3), and 628 kJ] or a noncaloric placebo (control group) before breakfast for 6wk.Mixedmuscle protein fractional synthesis rate (FSR)wasmeasured atweek 0 in the basal and postprandial state, after study product intake with a standardized breakfast with the use of L-[2H5]-phenylalanine tracer methodology. The longer-term effect of the medical nutrition drink was evaluated by measurement of appendicular lean mass, representing skeletal muscle mass at weeks 0 and 6, by dual-energy X-ray absorptiometry. Results: Postprandial FSR (0-240 min) was higher in the test group than in the control group [estimate of difference (ED): 0.022%/h; 95% CI: 0.010%/h, 0.035%/h; ANCOVA, P = 0.001]. The test group gained more appendicular lean mass than the control group after 6 wk (ED: 0.37 kg; 95% CI: 0.03, 0.72 kg; ANCOVA, P = 0.035), predominantly as leg lean mass (ED: 0.30 kg; 95% CI: 0.03, 0.57 kg; ANCOVA, P = 0.034). Conclusions: Supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink stimulated postprandial muscle protein synthesis and increased muscle mass after 6 wk of intervention in healthy older adults and may therefore be a way to support muscle preservation in older people.
KW - Leucine
KW - Muscle mass
KW - Muscle protein synthesis
KW - Protein intake
KW - Sarcopenia
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85036559090&partnerID=8YFLogxK
U2 - 10.3945/jn.117.252510
DO - 10.3945/jn.117.252510
M3 - Article
C2 - 28835387
AN - SCOPUS:85036559090
VL - 147
SP - 2262
EP - 2271
JO - The Journal of nutrition
JF - The Journal of nutrition
SN - 0022-3166
IS - 12
ER -