Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A

Taco J De Vries, Wendy de Vries, Mieke C W Janssen, Anton N M Schoffelmeer

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The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.

Original languageEnglish
Pages (from-to)164-8
Number of pages5
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - 3 Jun 2005

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