Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A

Taco J De Vries, Wendy de Vries, Mieke C W Janssen, Anton N M Schoffelmeer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.

Original languageEnglish
Pages (from-to)164-8
Number of pages5
JournalBehavioural Brain Research
Volume161
Issue number1
DOIs
Publication statusPublished - 3 Jun 2005

Cite this

De Vries, Taco J ; de Vries, Wendy ; Janssen, Mieke C W ; Schoffelmeer, Anton N M. / Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A. In: Behavioural Brain Research. 2005 ; Vol. 161, No. 1. pp. 164-8.
@article{f21ea293ff784eb790e6865dce235182,
title = "Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A",
abstract = "The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.",
keywords = "Animals, Behavior, Animal, Cannabinoid Receptor Antagonists, Conditioning, Operant, Dose-Response Relationship, Drug, Drug Interactions, Extinction, Psychological, Inhibition (Psychology), Male, Nicotine, Nicotinic Agonists, Piperidines, Pyrazoles, Rats, Rats, Wistar, Sucrose, Sweetening Agents, Comparative Study, Journal Article",
author = "{De Vries}, {Taco J} and {de Vries}, Wendy and Janssen, {Mieke C W} and Schoffelmeer, {Anton N M}",
year = "2005",
month = "6",
day = "3",
doi = "10.1016/j.bbr.2005.02.021",
language = "English",
volume = "161",
pages = "164--8",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A. / De Vries, Taco J; de Vries, Wendy; Janssen, Mieke C W; Schoffelmeer, Anton N M.

In: Behavioural Brain Research, Vol. 161, No. 1, 03.06.2005, p. 164-8.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A

AU - De Vries, Taco J

AU - de Vries, Wendy

AU - Janssen, Mieke C W

AU - Schoffelmeer, Anton N M

PY - 2005/6/3

Y1 - 2005/6/3

N2 - The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.

AB - The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.

KW - Animals

KW - Behavior, Animal

KW - Cannabinoid Receptor Antagonists

KW - Conditioning, Operant

KW - Dose-Response Relationship, Drug

KW - Drug Interactions

KW - Extinction, Psychological

KW - Inhibition (Psychology)

KW - Male

KW - Nicotine

KW - Nicotinic Agonists

KW - Piperidines

KW - Pyrazoles

KW - Rats

KW - Rats, Wistar

KW - Sucrose

KW - Sweetening Agents

KW - Comparative Study

KW - Journal Article

U2 - 10.1016/j.bbr.2005.02.021

DO - 10.1016/j.bbr.2005.02.021

M3 - Article

VL - 161

SP - 164

EP - 168

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -