Il trattamento chirurgico del carcinoma a cellule squamose dell’osso temporale: Fattori predittivi di sopravvivenza

Translated title of the contribution: Surgical treatment for squamous cell carcinoma of the temporal bone: Predictors of survival

Conrad F. Smit*, Niels de Boer, Birgit I. Lissenberg-Witte, Paul Merkus, Erik F. Hensen, C. René Leemans

*Corresponding author for this work

Research output: Contribution to journalArticleProfessional

Abstract

Objective. Evaluation of the management and survival in patients treated for temporal bone squamous cell carcinoma (TBSCC) in a tertiary referral centre. Methods. Forty-nine patients underwent primary treatment for TBSCC. Thirty-six patients underwent a lateral temporal bone resection (LTBR) or subtotal temporal bone resection (STBR). Overall survival (OS) and disease-specific survival (DSS) analysis were assessed. Results. Five-year OS of the 49 patients was 39%. Five-year OS of the 36 patients who underwent LTBR or STBR was 46%. Tumour-free margins were achieved in all patients with T1 and T2 disease, in 59% patients with T3 tumours and 0% patients with T4 disease. Five-year DSS was 85% for all T1/T2 tumours, 53% for T3 tumours and 0% for T4 tumours. Clear resection margins was the only significant predictor of DSS in our cohort. Conclusions. The mainstay of treatment for TBSCC is temporal bone resection with tumour free resection margins, with or without adjuvant radiotherapy. Survival is negatively influenced by non-radical resection. T1 and T2 tumours can be managed safely with LTBR. More advanced disease requires a more extensive resection, with a higher likelihood of non-radical resections and decreased survival rates.
Translated title of the contributionSurgical treatment for squamous cell carcinoma of the temporal bone: Predictors of survival
Original languageItalian
Pages (from-to)308-316
Number of pages9
JournalActa otorhinolaryngologica italica
Volume41
Issue number4
DOIs
Publication statusPublished - 1 Aug 2021

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