Sustained activation does not desensitize the dopamine D2 receptor-mediated control of evoked in vitro release of radiolabeled acetylcholine from rat striatum

B Drukarch, E Schepens, J C Stoof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Striatal acetylcholine release is decreased on activation of D2 dopamine receptors. In the present study, it was investigated whether sustained activation of these receptors would reduce their capacity to mediate this effect. It was shown that activation for up to 2 h with high concentrations of either the endogenous ligand, dopamine, or the selective D2 receptor agonist, LY 171555, did not induce desensitization of the D2 receptor-mediated inhibited of electrically evoked [3H]acetylcholine release from rat striatal tissue slices.

Original languageEnglish
Pages (from-to)209-12
Number of pages4
JournalEuropean Journal of Pharmacology
Volume196
Issue number2
Publication statusPublished - 17 Apr 1991

Cite this

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title = "Sustained activation does not desensitize the dopamine D2 receptor-mediated control of evoked in vitro release of radiolabeled acetylcholine from rat striatum",
abstract = "Striatal acetylcholine release is decreased on activation of D2 dopamine receptors. In the present study, it was investigated whether sustained activation of these receptors would reduce their capacity to mediate this effect. It was shown that activation for up to 2 h with high concentrations of either the endogenous ligand, dopamine, or the selective D2 receptor agonist, LY 171555, did not induce desensitization of the D2 receptor-mediated inhibited of electrically evoked [3H]acetylcholine release from rat striatal tissue slices.",
keywords = "Acetylcholine, Animals, Corpus Striatum, Dopamine, Dopamine Agents, Electric Stimulation, Ergolines, In Vitro Techniques, Male, Quinpirole, Rats, Receptors, Dopamine, Journal Article",
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year = "1991",
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language = "English",
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journal = "European Journal of Pharmacology",
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Sustained activation does not desensitize the dopamine D2 receptor-mediated control of evoked in vitro release of radiolabeled acetylcholine from rat striatum. / Drukarch, B; Schepens, E; Stoof, J C.

In: European Journal of Pharmacology, Vol. 196, No. 2, 17.04.1991, p. 209-12.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Sustained activation does not desensitize the dopamine D2 receptor-mediated control of evoked in vitro release of radiolabeled acetylcholine from rat striatum

AU - Drukarch, B

AU - Schepens, E

AU - Stoof, J C

PY - 1991/4/17

Y1 - 1991/4/17

N2 - Striatal acetylcholine release is decreased on activation of D2 dopamine receptors. In the present study, it was investigated whether sustained activation of these receptors would reduce their capacity to mediate this effect. It was shown that activation for up to 2 h with high concentrations of either the endogenous ligand, dopamine, or the selective D2 receptor agonist, LY 171555, did not induce desensitization of the D2 receptor-mediated inhibited of electrically evoked [3H]acetylcholine release from rat striatal tissue slices.

AB - Striatal acetylcholine release is decreased on activation of D2 dopamine receptors. In the present study, it was investigated whether sustained activation of these receptors would reduce their capacity to mediate this effect. It was shown that activation for up to 2 h with high concentrations of either the endogenous ligand, dopamine, or the selective D2 receptor agonist, LY 171555, did not induce desensitization of the D2 receptor-mediated inhibited of electrically evoked [3H]acetylcholine release from rat striatal tissue slices.

KW - Acetylcholine

KW - Animals

KW - Corpus Striatum

KW - Dopamine

KW - Dopamine Agents

KW - Electric Stimulation

KW - Ergolines

KW - In Vitro Techniques

KW - Male

KW - Quinpirole

KW - Rats

KW - Receptors, Dopamine

KW - Journal Article

M3 - Article

VL - 196

SP - 209

EP - 212

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -