Synaptic Loss in Multiple Sclerosis Spinal Cord

Natalia Petrova, Erik Nutma, Daniele Carassiti, James Rs Newman, Sandra Amor, Daniel R Altmann, David Baker, Klaus Schmierer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area—a predictor of disability—is poor, questioning the unique role of axonal loss. We investigated the degree of synaptic loss in postmortem spinal cords (18 chronic MS, 8 healthy controls) using immunohistochemistry for synaptophysin and synapsin. Substantial (58–96%) loss of synapses throughout the spinal cord was detected, along with moderate (47%) loss of anterior horn neurons, notably in demyelinating MS lesions. We conclude that synaptic loss is significant in chronic MS, likely contributing to disability accrual. ANN NEUROL 2020;88:619–625.

Original languageEnglish
Pages (from-to)619-625
Number of pages7
JournalAnnals of Neurology
Volume88
Issue number3
Early online date30 Jun 2020
DOIs
Publication statusPublished - 1 Sep 2020

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