Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance

Barbara Parrino, Domenico Schillaci, Ilaria Carnevale, Elisa Giovannetti, Patrizia Diana, Girolamo Cirrincione, Stella Cascioferro

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Biofilm formation significantly contributes to microbial survival in hostile environments and it is currently considered a key virulence factor for pathogens responsible for serious chronic infections. In the last decade many efforts have been made to identify new agents able to modulate bacterial biofilm life cycle, and many compounds have shown interesting activities in inhibiting biofilm formation or in dispersing pre-formed biofilms. However, only a few of these compounds were tested using in vivo models for their clinical significance. Contrary to conventional antibiotics, most of the anti-biofilm compounds act as anti-virulence agents as they do not affect bacterial growth. In this review we selected the most relevant literature of the last decade, focusing on the development of synthetic small molecules able to prevent bacterial biofilm formation or to eradicate pre-existing biofilms of clinically relevant Gram-positive and Gram-negative pathogens. In addition, we provide a comprehensive list of the possible targets to counteract biofilm formation and development, as well as a detailed discussion the advantages and disadvantages of the different current biofilm-targeting strategies.
LanguageEnglish
Pages154-178
JournalEuropean Journal of Medicinal Chemistry
Volume161
DOIs
StatePublished - 2019

Cite this

Parrino, B., Schillaci, D., Carnevale, I., Giovannetti, E., Diana, P., Cirrincione, G., & Cascioferro, S. (2019). Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance. European Journal of Medicinal Chemistry, 161, 154-178. DOI: 10.1016/j.ejmech.2018.10.036
Parrino, Barbara ; Schillaci, Domenico ; Carnevale, Ilaria ; Giovannetti, Elisa ; Diana, Patrizia ; Cirrincione, Girolamo ; Cascioferro, Stella. / Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance. In: European Journal of Medicinal Chemistry. 2019 ; Vol. 161. pp. 154-178
@article{6c2f8cee42a94d11acc0e623993a2b3c,
title = "Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance",
abstract = "Biofilm formation significantly contributes to microbial survival in hostile environments and it is currently considered a key virulence factor for pathogens responsible for serious chronic infections. In the last decade many efforts have been made to identify new agents able to modulate bacterial biofilm life cycle, and many compounds have shown interesting activities in inhibiting biofilm formation or in dispersing pre-formed biofilms. However, only a few of these compounds were tested using in vivo models for their clinical significance. Contrary to conventional antibiotics, most of the anti-biofilm compounds act as anti-virulence agents as they do not affect bacterial growth. In this review we selected the most relevant literature of the last decade, focusing on the development of synthetic small molecules able to prevent bacterial biofilm formation or to eradicate pre-existing biofilms of clinically relevant Gram-positive and Gram-negative pathogens. In addition, we provide a comprehensive list of the possible targets to counteract biofilm formation and development, as well as a detailed discussion the advantages and disadvantages of the different current biofilm-targeting strategies.",
author = "Barbara Parrino and Domenico Schillaci and Ilaria Carnevale and Elisa Giovannetti and Patrizia Diana and Girolamo Cirrincione and Stella Cascioferro",
year = "2019",
doi = "10.1016/j.ejmech.2018.10.036",
language = "English",
volume = "161",
pages = "154--178",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",

}

Parrino, B, Schillaci, D, Carnevale, I, Giovannetti, E, Diana, P, Cirrincione, G & Cascioferro, S 2019, 'Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance' European Journal of Medicinal Chemistry, vol. 161, pp. 154-178. DOI: 10.1016/j.ejmech.2018.10.036

Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance. / Parrino, Barbara; Schillaci, Domenico; Carnevale, Ilaria; Giovannetti, Elisa; Diana, Patrizia; Cirrincione, Girolamo; Cascioferro, Stella.

In: European Journal of Medicinal Chemistry, Vol. 161, 2019, p. 154-178.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance

AU - Parrino,Barbara

AU - Schillaci,Domenico

AU - Carnevale,Ilaria

AU - Giovannetti,Elisa

AU - Diana,Patrizia

AU - Cirrincione,Girolamo

AU - Cascioferro,Stella

PY - 2019

Y1 - 2019

N2 - Biofilm formation significantly contributes to microbial survival in hostile environments and it is currently considered a key virulence factor for pathogens responsible for serious chronic infections. In the last decade many efforts have been made to identify new agents able to modulate bacterial biofilm life cycle, and many compounds have shown interesting activities in inhibiting biofilm formation or in dispersing pre-formed biofilms. However, only a few of these compounds were tested using in vivo models for their clinical significance. Contrary to conventional antibiotics, most of the anti-biofilm compounds act as anti-virulence agents as they do not affect bacterial growth. In this review we selected the most relevant literature of the last decade, focusing on the development of synthetic small molecules able to prevent bacterial biofilm formation or to eradicate pre-existing biofilms of clinically relevant Gram-positive and Gram-negative pathogens. In addition, we provide a comprehensive list of the possible targets to counteract biofilm formation and development, as well as a detailed discussion the advantages and disadvantages of the different current biofilm-targeting strategies.

AB - Biofilm formation significantly contributes to microbial survival in hostile environments and it is currently considered a key virulence factor for pathogens responsible for serious chronic infections. In the last decade many efforts have been made to identify new agents able to modulate bacterial biofilm life cycle, and many compounds have shown interesting activities in inhibiting biofilm formation or in dispersing pre-formed biofilms. However, only a few of these compounds were tested using in vivo models for their clinical significance. Contrary to conventional antibiotics, most of the anti-biofilm compounds act as anti-virulence agents as they do not affect bacterial growth. In this review we selected the most relevant literature of the last decade, focusing on the development of synthetic small molecules able to prevent bacterial biofilm formation or to eradicate pre-existing biofilms of clinically relevant Gram-positive and Gram-negative pathogens. In addition, we provide a comprehensive list of the possible targets to counteract biofilm formation and development, as well as a detailed discussion the advantages and disadvantages of the different current biofilm-targeting strategies.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055027776&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30347328

U2 - 10.1016/j.ejmech.2018.10.036

DO - 10.1016/j.ejmech.2018.10.036

M3 - Review article

VL - 161

SP - 154

EP - 178

JO - European Journal of Medicinal Chemistry

T2 - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -