T-cell differentiation in lethally irradiated and reconstituted mice

G. Kraal; A. A. Geldof; D. Boden

doi:10.1016/0008-8749(80)90061-1

T-cell differentiation in lethally irradiated and reconstituted mice

G. Kraal^*, A. A. Geldof, D. Boden

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

During the first 3 days after irradiation and reconstitution (IR) with hemopoietic stem cells a small number of cells with the capacity to form colonies (CFU-s) can be detected in the thymus. This number is increased when thymectomized mice are used as recipients for colony determination. In thymus-cell suspensions from animals 4 days after IR no CFU-s can be found either in normal or in thymectomized recipients. Tracer studies with ¹¹¹In-labeled oxine revealed that thymocytes obtained from animals 3 days after IR contain a large number of cells with a strong preference for the thymus. This number decreases in the following days after irradiation; these cells are thought to represent an intermediate cell between stem cell and T cell.

Original language	English
Pages (from-to)	110-119
Number of pages	10
Journal	Cellular Immunology
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(80)90061-1
Publication status	Published - 1 Jan 1980

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AB - During the first 3 days after irradiation and reconstitution (IR) with hemopoietic stem cells a small number of cells with the capacity to form colonies (CFU-s) can be detected in the thymus. This number is increased when thymectomized mice are used as recipients for colony determination. In thymus-cell suspensions from animals 4 days after IR no CFU-s can be found either in normal or in thymectomized recipients. Tracer studies with 111In-labeled oxine revealed that thymocytes obtained from animals 3 days after IR contain a large number of cells with a strong preference for the thymus. This number decreases in the following days after irradiation; these cells are thought to represent an intermediate cell between stem cell and T cell.

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T-cell differentiation in lethally irradiated and reconstituted mice

Abstract

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