T-cell differentiation in lethally irradiated and reconstituted mice

G. Kraal, A. A. Geldof, D. Boden

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

During the first 3 days after irradiation and reconstitution (IR) with hemopoietic stem cells a small number of cells with the capacity to form colonies (CFU-s) can be detected in the thymus. This number is increased when thymectomized mice are used as recipients for colony determination. In thymus-cell suspensions from animals 4 days after IR no CFU-s can be found either in normal or in thymectomized recipients. Tracer studies with 111In-labeled oxine revealed that thymocytes obtained from animals 3 days after IR contain a large number of cells with a strong preference for the thymus. This number decreases in the following days after irradiation; these cells are thought to represent an intermediate cell between stem cell and T cell.

Original languageEnglish
Pages (from-to)110-119
Number of pages10
JournalCellular Immunology
Volume49
Issue number1
DOIs
Publication statusPublished - 1 Jan 1980

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