T-cell progenitor function during progressive human immunodeficiency virus-1 infection and after antiretroviral therapy

Dawn R. Clark, Sjoerd Repping, Nadine G. Pakker, Jan M. Prins, Daan W. Notermans, Ferdinand W.N.M. Wit, Peter Reiss, Sven A. Danner, Roel A. Coutinho, Joep M.A. Lange, Frank Miedema*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Impairment of T-cell renewal has been proposed as contributing to CD4+ T-cell depletion in persons infected with human immunodeficiency virus-1. We analyzed the T-cell development capacity of progenitors using fetal thymus organ culture. Those who progressed to AIDS had a dramatic loss in T-cell development capacity shortly after seroconversion. In contrast, long-term nonprogressors retained progenitor capacity 8 years after seroconversion. Approximately 70% of patients experienced an improvement in T-cell development capacity after receiving 6 months of potent antiretroviral therapy. Improvement in T-cell development in fetal thymus organ culture correlated with an increase in the number of naive CD4+ T cells in peripheral blood. Numbers of progenitors in blood and bone marrow after seroconversion or during therapy did not correlate with the change observed in T-cell development capacity. These data provide evidence that HIV-1 infection can interfere with T-cell renewal at the level of the progenitor cell. Interference with T-cell renewal may contribute to CD4+ T-cell depletion. (C) 2000 by The American Society of Hematology.

Original languageEnglish
Pages (from-to)242-249
Number of pages8
Issue number1
Publication statusPublished - 1 Jul 2000

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