Temporal changes in left ventricular longitudinal strain in general population: Clinical correlates and impact on cardiac remodeling

Tatiana Kuznetsova, Ellen Nijs, Nicholas Cauwenberghs, Judita Knez, Lutgarde Thijs, Francois Haddad, Wen-Yi Yang, Peter L. Kerkhof, Jens-Uwe Voigt, Jan A. Staessen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Recent studies in patients and general population have reported the role of left ventricular (LV) longitudinal strain (LS) as an independent predictor of outcome. However, there are few data on changes in LS over time. We therefore investigated in a general population clinical correlates of temporal changes in LS. We also explored the potential correlation between temporal changes in LV volumes and LS. Methods and Results: We measured LV end-systolic (ESV) and end-diastolic (EDV) volumes by conventional echocardiography and LS by 2D speckle tracking in 627 participants (mean age 50.6 years, 51.4% women; 41.3% hypertensives) at baseline and after 4.7 years. For statistical analysis, we used the absolute values of LS. In stepwise regression, the magnitude of the decrease in all LV LS indexes over time was greater in men than in women (P < 0.0001). Higher baseline mean arterial pressure (MAP), a larger longitudinal increase in MAP, and stopping diuretic treatment during follow-up were related to larger decreases in LS indexes. In multivariable-adjusted analysis, we observed an inverse correlation between baseline ESV and LV LS (P ≤ 0.0017). Similarly, lower baseline LS and a larger decrease in LS over time were correlated with a lesser longitudinal decrease in ESV (P ≤ 0.0004). Conclusions: A significant decrease in LS over time was associated with male sex, higher baseline MAP, ∆MAP, and alteration in antihypertensive treatment. We suggested an interaction between a longitudinal decrease in LV deformation and adverse cardiac remodeling, while underscoring the importance of deformation analysis based on LS assessment in patients at risk.

Original languageEnglish
Pages (from-to)458-468
Number of pages11
JournalEchocardiography
Volume36
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019

Cite this

Kuznetsova, T., Nijs, E., Cauwenberghs, N., Knez, J., Thijs, L., Haddad, F., ... Staessen, J. A. (2019). Temporal changes in left ventricular longitudinal strain in general population: Clinical correlates and impact on cardiac remodeling. Echocardiography, 36(3), 458-468. https://doi.org/10.1111/echo.14246
Kuznetsova, Tatiana ; Nijs, Ellen ; Cauwenberghs, Nicholas ; Knez, Judita ; Thijs, Lutgarde ; Haddad, Francois ; Yang, Wen-Yi ; Kerkhof, Peter L. ; Voigt, Jens-Uwe ; Staessen, Jan A. / Temporal changes in left ventricular longitudinal strain in general population: Clinical correlates and impact on cardiac remodeling. In: Echocardiography. 2019 ; Vol. 36, No. 3. pp. 458-468.
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abstract = "Background: Recent studies in patients and general population have reported the role of left ventricular (LV) longitudinal strain (LS) as an independent predictor of outcome. However, there are few data on changes in LS over time. We therefore investigated in a general population clinical correlates of temporal changes in LS. We also explored the potential correlation between temporal changes in LV volumes and LS. Methods and Results: We measured LV end-systolic (ESV) and end-diastolic (EDV) volumes by conventional echocardiography and LS by 2D speckle tracking in 627 participants (mean age 50.6 years, 51.4{\%} women; 41.3{\%} hypertensives) at baseline and after 4.7 years. For statistical analysis, we used the absolute values of LS. In stepwise regression, the magnitude of the decrease in all LV LS indexes over time was greater in men than in women (P < 0.0001). Higher baseline mean arterial pressure (MAP), a larger longitudinal increase in MAP, and stopping diuretic treatment during follow-up were related to larger decreases in LS indexes. In multivariable-adjusted analysis, we observed an inverse correlation between baseline ESV and LV LS (P ≤ 0.0017). Similarly, lower baseline LS and a larger decrease in LS over time were correlated with a lesser longitudinal decrease in ESV (P ≤ 0.0004). Conclusions: A significant decrease in LS over time was associated with male sex, higher baseline MAP, ∆MAP, and alteration in antihypertensive treatment. We suggested an interaction between a longitudinal decrease in LV deformation and adverse cardiac remodeling, while underscoring the importance of deformation analysis based on LS assessment in patients at risk.",
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Kuznetsova, T, Nijs, E, Cauwenberghs, N, Knez, J, Thijs, L, Haddad, F, Yang, W-Y, Kerkhof, PL, Voigt, J-U & Staessen, JA 2019, 'Temporal changes in left ventricular longitudinal strain in general population: Clinical correlates and impact on cardiac remodeling' Echocardiography, vol. 36, no. 3, pp. 458-468. https://doi.org/10.1111/echo.14246

Temporal changes in left ventricular longitudinal strain in general population: Clinical correlates and impact on cardiac remodeling. / Kuznetsova, Tatiana; Nijs, Ellen; Cauwenberghs, Nicholas; Knez, Judita; Thijs, Lutgarde; Haddad, Francois; Yang, Wen-Yi; Kerkhof, Peter L.; Voigt, Jens-Uwe; Staessen, Jan A.

In: Echocardiography, Vol. 36, No. 3, 01.03.2019, p. 458-468.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Temporal changes in left ventricular longitudinal strain in general population: Clinical correlates and impact on cardiac remodeling

AU - Kuznetsova, Tatiana

AU - Nijs, Ellen

AU - Cauwenberghs, Nicholas

AU - Knez, Judita

AU - Thijs, Lutgarde

AU - Haddad, Francois

AU - Yang, Wen-Yi

AU - Kerkhof, Peter L.

AU - Voigt, Jens-Uwe

AU - Staessen, Jan A.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Recent studies in patients and general population have reported the role of left ventricular (LV) longitudinal strain (LS) as an independent predictor of outcome. However, there are few data on changes in LS over time. We therefore investigated in a general population clinical correlates of temporal changes in LS. We also explored the potential correlation between temporal changes in LV volumes and LS. Methods and Results: We measured LV end-systolic (ESV) and end-diastolic (EDV) volumes by conventional echocardiography and LS by 2D speckle tracking in 627 participants (mean age 50.6 years, 51.4% women; 41.3% hypertensives) at baseline and after 4.7 years. For statistical analysis, we used the absolute values of LS. In stepwise regression, the magnitude of the decrease in all LV LS indexes over time was greater in men than in women (P < 0.0001). Higher baseline mean arterial pressure (MAP), a larger longitudinal increase in MAP, and stopping diuretic treatment during follow-up were related to larger decreases in LS indexes. In multivariable-adjusted analysis, we observed an inverse correlation between baseline ESV and LV LS (P ≤ 0.0017). Similarly, lower baseline LS and a larger decrease in LS over time were correlated with a lesser longitudinal decrease in ESV (P ≤ 0.0004). Conclusions: A significant decrease in LS over time was associated with male sex, higher baseline MAP, ∆MAP, and alteration in antihypertensive treatment. We suggested an interaction between a longitudinal decrease in LV deformation and adverse cardiac remodeling, while underscoring the importance of deformation analysis based on LS assessment in patients at risk.

AB - Background: Recent studies in patients and general population have reported the role of left ventricular (LV) longitudinal strain (LS) as an independent predictor of outcome. However, there are few data on changes in LS over time. We therefore investigated in a general population clinical correlates of temporal changes in LS. We also explored the potential correlation between temporal changes in LV volumes and LS. Methods and Results: We measured LV end-systolic (ESV) and end-diastolic (EDV) volumes by conventional echocardiography and LS by 2D speckle tracking in 627 participants (mean age 50.6 years, 51.4% women; 41.3% hypertensives) at baseline and after 4.7 years. For statistical analysis, we used the absolute values of LS. In stepwise regression, the magnitude of the decrease in all LV LS indexes over time was greater in men than in women (P < 0.0001). Higher baseline mean arterial pressure (MAP), a larger longitudinal increase in MAP, and stopping diuretic treatment during follow-up were related to larger decreases in LS indexes. In multivariable-adjusted analysis, we observed an inverse correlation between baseline ESV and LV LS (P ≤ 0.0017). Similarly, lower baseline LS and a larger decrease in LS over time were correlated with a lesser longitudinal decrease in ESV (P ≤ 0.0004). Conclusions: A significant decrease in LS over time was associated with male sex, higher baseline MAP, ∆MAP, and alteration in antihypertensive treatment. We suggested an interaction between a longitudinal decrease in LV deformation and adverse cardiac remodeling, while underscoring the importance of deformation analysis based on LS assessment in patients at risk.

KW - cardiac remodeling

KW - general population

KW - left ventricular strain

KW - longitudinal changes

KW - systolic function

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30609050

U2 - 10.1111/echo.14246

DO - 10.1111/echo.14246

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