Temporal profile of body temperature in acute ischemic stroke: Relation to infarct size and outcome

Marjolein Geurts*, Féline E.V. Scheijmans, Tom van Seeters, Geert Jan Biessels, L. Jaap Kappelle, Birgitta K. Velthuis, H. Bart van der Worp, C.B. Majoie, Y.B. Roos, L.E. Duijm, K. Keizer, A. van der Lugt, D.W. Dippel, Droogh de Greve, H.P. Bienfait, Marianne A. A. van Walderveen, M.J. Wermer, G. J. Lycklama à Nijeholt, J. Boiten, D.A. DuyndamV.I.H. Kwa, Frederick J. A. Meijer, E. J. van Dijk, F.O. Kesselring, J. Hofmeijer, J. A. Vos, Wouter J. Schonewille, W.J.J. van Rooij, P.L. de Kort, C. Constantijn Pleiter, S. L. Bakker, J. Bot, M. C. Visser, Birgitta K. Velthuis, Irene C. van der Schaaf, J.W. Dankbaar, W.P. Mali, T. van Seeters, Alexander D. Horsch, Joris M. Niesten, G.J. Biessels, L. Jaap Kappelle, M.J. Luitse, Y. van der Graaf, on behalf of the DUST investigators

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: High body temperatures after ischemic stroke have been associated with larger infarct size, but the temporal profile of this relation is unknown. We assess the relation between temporal profile of body temperature and infarct size and functional outcome in patients with acute ischemic stroke. Methods: In 419 patients with acute ischemic stroke we assessed the relation between body temperature on admission and during the first 3 days with both infarct size and functional outcome. Infarct size was measured in milliliters on CT or MRI after 3 days. Poor functional outcome was defined as a modified Rankin Scale score ≥3 at 3 months. Results: Body temperature on admission was not associated with infarct size or poor outcome in adjusted analyses. By contrast, each additional 1.0 °C in body temperature on day 1 was associated with 0.31 ml larger infarct size (95% confidence interval (CI) 0.04-0.59), on day 2 with 1.13 ml larger infarct size(95% CI, 0.83-1.43), and on day 3 with 0.80 ml larger infarct size (95% CI, 0.48-1.12), in adjusted linear regression analyses. Higher peak body temperatures on days two and three were also associated with poor outcome (adjusted relative risks per additional 1.0 °C in body temperature, 1.52 (95% CI, 1.17-1.99) and 1.47 (95% CI, 1.22-1.77), respectively). Conclusions: Higher peak body temperatures during the first days after ischemic stroke, rather than on admission, are associated with larger infarct size and poor functional outcome. This suggests that prevention of high temperatures may improve outcome if continued for at least 3 days.

Original languageEnglish
Article number233
JournalBMC Neurology
Issue number1
Publication statusPublished - 21 Nov 2016

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