Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role

Catarina Gago da Graça, Lisa G M van Baarsen, Reina E Mebius

Research output: Contribution to journalReview articleAcademicpeer-review


Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid organs, providing both a structural matrix and soluble factors that regulate survival and migration of immune cells, ultimately promoting Ag encounter. In several inflamed tissues, resident fibroblasts can acquire lymphoid-stroma properties and drive the formation of ectopic aggregates of immune cells, named tertiary lymphoid structures (TLSs). Mature TLSs are functional sites for the development of adaptive responses and, consequently, when present, can have an impact in both autoimmunity and cancer conditions. In this review, we go over recent findings concerning both lymph node stromal cells and TLSs function and formation and further describe what is currently known about their role in disease, particularly their potential in tolerance.

Original languageEnglish
Pages (from-to)273-281
Number of pages9
JournalJournal of Immunology
Issue number2
Publication statusPublished - 15 Jan 2021

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