Thallium-201 SPECT as response parameter for PCV chemotherapy in recurrent glioma

M. F. Roesdi; T. J. Postma; O. S. Hoekstra; C. J. Van Groeningen; J. G. Wolbers; J. J. Heimans

doi:10.1023/A:1006090807678

Thallium-201 SPECT as response parameter for PCV chemotherapy in recurrent glioma

M. F. Roesdi^*, T. J. Postma, O. S. Hoekstra, C. J. Van Groeningen, J. G. Wolbers, J. J. Heimans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Combination chemotherapy with procarbazine, CCNU and vincristine (PCV) may be effective in patients with recurrent glioma. Response monitoring is mandatory, but radiological response evaluation is often difficult. We evaluated Thallium-201 (²⁰¹Tl) SPECT as a response parameter in ten patients treated with intensive PCV chemotherapy for recurrent glioma. ²⁰¹Tl-SPECT studies showed early changes (decreasing volume and intensity) in nine patients and these changes were more pronounced than radiological findings. ²⁰¹Tl-SPECT results after completion of chemotherapy seemed to correlate with clininal findings during follow up. We conclude that ²⁰¹Tl-SPECT may contribute to the assessment of response in patients treated with PCV chemotherapy for recurrent glioma.

Original language	English
Pages (from-to)	251-255
Number of pages	5
Journal	Journal of Neuro-Oncology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1023/A:1006090807678
Publication status	Published - 1998

Access to Document

10.1023/A:1006090807678

Cite this

@article{8b95228a19804031bf416dbc4e78226b,

title = "Thallium-201 SPECT as response parameter for PCV chemotherapy in recurrent glioma",

abstract = "Combination chemotherapy with procarbazine, CCNU and vincristine (PCV) may be effective in patients with recurrent glioma. Response monitoring is mandatory, but radiological response evaluation is often difficult. We evaluated Thallium-201 (201Tl) SPECT as a response parameter in ten patients treated with intensive PCV chemotherapy for recurrent glioma. 201Tl-SPECT studies showed early changes (decreasing volume and intensity) in nine patients and these changes were more pronounced than radiological findings. 201Tl-SPECT results after completion of chemotherapy seemed to correlate with clininal findings during follow up. We conclude that 201Tl-SPECT may contribute to the assessment of response in patients treated with PCV chemotherapy for recurrent glioma.",

keywords = "Chemotherapy, Recurrent glioma, Response parameter, Thallium-201 SPECT",

author = "Roesdi, {M. F.} and Postma, {T. J.} and Hoekstra, {O. S.} and {Van Groeningen}, {C. J.} and Wolbers, {J. G.} and Heimans, {J. J.}",

year = "1998",

doi = "10.1023/A:1006090807678",

language = "English",

volume = "40",

pages = "251--255",

journal = "Journal of Neuro-Oncology",

issn = "0167-594X",

publisher = "Kluwer Academic Publishers",

number = "3",

}

TY - JOUR

T1 - Thallium-201 SPECT as response parameter for PCV chemotherapy in recurrent glioma

AU - Roesdi, M. F.

AU - Postma, T. J.

AU - Hoekstra, O. S.

AU - Van Groeningen, C. J.

AU - Wolbers, J. G.

AU - Heimans, J. J.

PY - 1998

Y1 - 1998

N2 - Combination chemotherapy with procarbazine, CCNU and vincristine (PCV) may be effective in patients with recurrent glioma. Response monitoring is mandatory, but radiological response evaluation is often difficult. We evaluated Thallium-201 (201Tl) SPECT as a response parameter in ten patients treated with intensive PCV chemotherapy for recurrent glioma. 201Tl-SPECT studies showed early changes (decreasing volume and intensity) in nine patients and these changes were more pronounced than radiological findings. 201Tl-SPECT results after completion of chemotherapy seemed to correlate with clininal findings during follow up. We conclude that 201Tl-SPECT may contribute to the assessment of response in patients treated with PCV chemotherapy for recurrent glioma.

AB - Combination chemotherapy with procarbazine, CCNU and vincristine (PCV) may be effective in patients with recurrent glioma. Response monitoring is mandatory, but radiological response evaluation is often difficult. We evaluated Thallium-201 (201Tl) SPECT as a response parameter in ten patients treated with intensive PCV chemotherapy for recurrent glioma. 201Tl-SPECT studies showed early changes (decreasing volume and intensity) in nine patients and these changes were more pronounced than radiological findings. 201Tl-SPECT results after completion of chemotherapy seemed to correlate with clininal findings during follow up. We conclude that 201Tl-SPECT may contribute to the assessment of response in patients treated with PCV chemotherapy for recurrent glioma.

KW - Chemotherapy

KW - Recurrent glioma

KW - Response parameter

KW - Thallium-201 SPECT

UR - http://www.scopus.com/inward/record.url?scp=0032411325&partnerID=8YFLogxK

U2 - 10.1023/A:1006090807678

DO - 10.1023/A:1006090807678

M3 - Article

C2 - 10066098

AN - SCOPUS:0032411325

SN - 0167-594X

VL - 40

SP - 251

EP - 255

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

IS - 3

ER -

Thallium-201 SPECT as response parameter for PCV chemotherapy in recurrent glioma

Abstract

Access to Document

Other files and links

Cite this