The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description

Henne Holstege, Nina Beker, Tjitske Dijkstra, Karlijn Pieterse, Elizabeth Wemmenhove, Kimja Schouten, Linette Thiessens, Debbie Horsten, Sterre Rechtuijt, Sietske Sikkes, Frans W A van Poppel, Hanne Meijers-Heijboer, Marc Hulsman, Philip Scheltens

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Although the incidence of dementia increases exponentially with age, some individuals reach more than 100 years with fully retained cognitive abilities. To identify the characteristics associated with the escape or delay of cognitive decline, we initiated the 100-plus Study ( www.100plus.nl ). The 100-plus Study is an on-going prospective cohort study of Dutch centenarians who self-reported to be cognitively healthy, their first-degree family members and their respective partners. We collect demographics, life history, medical history, genealogy, neuropsychological data and blood samples. Centenarians are followed annually until death. PET-MRI scans and feces donation are optional. Almost 30% of the centenarians agreed to post-mortem brain donation. To date (September 2018), 332 centenarians were included in the study. We analyzed demographic statistics of the first 300 centenarians (25% males) included in the cohort. Centenarians came from higher socio-economic classes and had higher levels of education compared to their birth cohort; alcohol consumption of centenarians was similar, and most males smoked during their lifetime. At baseline, the centenarians had a median MMSE score of 25 points (IQR 22.0-27.5); most centenarians lived independently, retained hearing and vision abilities and were independently mobile. Mortality was associated with cognitive functioning: centenarians with a baseline MMSE score ≥ 26 points had a mortality percentage of 17% per annual year in the second year after baseline, while centenarians with a baseline MMSE score < 26 points had a mortality of 42% per annual year (p = 0.003). The cohort was 2.1-fold enriched with the neuroprotective APOE-ε2 allele relative to 60-80 year-old population controls (p = 4.8 × 10-7), APOE-ε3 was unchanged and the APOE-ε4 allele was 2.3-fold depleted (p = 6.3 × 10-7). Comprehensive characterization of the 100-plus cohort of cognitively healthy centenarians might reveal protective factors that explain the physiology of long-term preserved cognitive health.

Original languageEnglish
JournalEuropean Journal of Epidemiology
DOIs
Publication statusE-pub ahead of print - 25 Oct 2018

Cite this

Holstege, Henne ; Beker, Nina ; Dijkstra, Tjitske ; Pieterse, Karlijn ; Wemmenhove, Elizabeth ; Schouten, Kimja ; Thiessens, Linette ; Horsten, Debbie ; Rechtuijt, Sterre ; Sikkes, Sietske ; van Poppel, Frans W A ; Meijers-Heijboer, Hanne ; Hulsman, Marc ; Scheltens, Philip. / The 100-plus Study of cognitively healthy centenarians : rationale, design and cohort description. In: European Journal of Epidemiology. 2018.
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abstract = "Although the incidence of dementia increases exponentially with age, some individuals reach more than 100 years with fully retained cognitive abilities. To identify the characteristics associated with the escape or delay of cognitive decline, we initiated the 100-plus Study ( www.100plus.nl ). The 100-plus Study is an on-going prospective cohort study of Dutch centenarians who self-reported to be cognitively healthy, their first-degree family members and their respective partners. We collect demographics, life history, medical history, genealogy, neuropsychological data and blood samples. Centenarians are followed annually until death. PET-MRI scans and feces donation are optional. Almost 30{\%} of the centenarians agreed to post-mortem brain donation. To date (September 2018), 332 centenarians were included in the study. We analyzed demographic statistics of the first 300 centenarians (25{\%} males) included in the cohort. Centenarians came from higher socio-economic classes and had higher levels of education compared to their birth cohort; alcohol consumption of centenarians was similar, and most males smoked during their lifetime. At baseline, the centenarians had a median MMSE score of 25 points (IQR 22.0-27.5); most centenarians lived independently, retained hearing and vision abilities and were independently mobile. Mortality was associated with cognitive functioning: centenarians with a baseline MMSE score ≥ 26 points had a mortality percentage of 17{\%} per annual year in the second year after baseline, while centenarians with a baseline MMSE score < 26 points had a mortality of 42{\%} per annual year (p = 0.003). The cohort was 2.1-fold enriched with the neuroprotective APOE-ε2 allele relative to 60-80 year-old population controls (p = 4.8 × 10-7), APOE-ε3 was unchanged and the APOE-ε4 allele was 2.3-fold depleted (p = 6.3 × 10-7). Comprehensive characterization of the 100-plus cohort of cognitively healthy centenarians might reveal protective factors that explain the physiology of long-term preserved cognitive health.",
author = "Henne Holstege and Nina Beker and Tjitske Dijkstra and Karlijn Pieterse and Elizabeth Wemmenhove and Kimja Schouten and Linette Thiessens and Debbie Horsten and Sterre Rechtuijt and Sietske Sikkes and {van Poppel}, {Frans W A} and Hanne Meijers-Heijboer and Marc Hulsman and Philip Scheltens",
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The 100-plus Study of cognitively healthy centenarians : rationale, design and cohort description. / Holstege, Henne; Beker, Nina; Dijkstra, Tjitske; Pieterse, Karlijn; Wemmenhove, Elizabeth; Schouten, Kimja; Thiessens, Linette; Horsten, Debbie; Rechtuijt, Sterre; Sikkes, Sietske; van Poppel, Frans W A; Meijers-Heijboer, Hanne; Hulsman, Marc; Scheltens, Philip.

In: European Journal of Epidemiology, 25.10.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The 100-plus Study of cognitively healthy centenarians

T2 - rationale, design and cohort description

AU - Holstege, Henne

AU - Beker, Nina

AU - Dijkstra, Tjitske

AU - Pieterse, Karlijn

AU - Wemmenhove, Elizabeth

AU - Schouten, Kimja

AU - Thiessens, Linette

AU - Horsten, Debbie

AU - Rechtuijt, Sterre

AU - Sikkes, Sietske

AU - van Poppel, Frans W A

AU - Meijers-Heijboer, Hanne

AU - Hulsman, Marc

AU - Scheltens, Philip

PY - 2018/10/25

Y1 - 2018/10/25

N2 - Although the incidence of dementia increases exponentially with age, some individuals reach more than 100 years with fully retained cognitive abilities. To identify the characteristics associated with the escape or delay of cognitive decline, we initiated the 100-plus Study ( www.100plus.nl ). The 100-plus Study is an on-going prospective cohort study of Dutch centenarians who self-reported to be cognitively healthy, their first-degree family members and their respective partners. We collect demographics, life history, medical history, genealogy, neuropsychological data and blood samples. Centenarians are followed annually until death. PET-MRI scans and feces donation are optional. Almost 30% of the centenarians agreed to post-mortem brain donation. To date (September 2018), 332 centenarians were included in the study. We analyzed demographic statistics of the first 300 centenarians (25% males) included in the cohort. Centenarians came from higher socio-economic classes and had higher levels of education compared to their birth cohort; alcohol consumption of centenarians was similar, and most males smoked during their lifetime. At baseline, the centenarians had a median MMSE score of 25 points (IQR 22.0-27.5); most centenarians lived independently, retained hearing and vision abilities and were independently mobile. Mortality was associated with cognitive functioning: centenarians with a baseline MMSE score ≥ 26 points had a mortality percentage of 17% per annual year in the second year after baseline, while centenarians with a baseline MMSE score < 26 points had a mortality of 42% per annual year (p = 0.003). The cohort was 2.1-fold enriched with the neuroprotective APOE-ε2 allele relative to 60-80 year-old population controls (p = 4.8 × 10-7), APOE-ε3 was unchanged and the APOE-ε4 allele was 2.3-fold depleted (p = 6.3 × 10-7). Comprehensive characterization of the 100-plus cohort of cognitively healthy centenarians might reveal protective factors that explain the physiology of long-term preserved cognitive health.

AB - Although the incidence of dementia increases exponentially with age, some individuals reach more than 100 years with fully retained cognitive abilities. To identify the characteristics associated with the escape or delay of cognitive decline, we initiated the 100-plus Study ( www.100plus.nl ). The 100-plus Study is an on-going prospective cohort study of Dutch centenarians who self-reported to be cognitively healthy, their first-degree family members and their respective partners. We collect demographics, life history, medical history, genealogy, neuropsychological data and blood samples. Centenarians are followed annually until death. PET-MRI scans and feces donation are optional. Almost 30% of the centenarians agreed to post-mortem brain donation. To date (September 2018), 332 centenarians were included in the study. We analyzed demographic statistics of the first 300 centenarians (25% males) included in the cohort. Centenarians came from higher socio-economic classes and had higher levels of education compared to their birth cohort; alcohol consumption of centenarians was similar, and most males smoked during their lifetime. At baseline, the centenarians had a median MMSE score of 25 points (IQR 22.0-27.5); most centenarians lived independently, retained hearing and vision abilities and were independently mobile. Mortality was associated with cognitive functioning: centenarians with a baseline MMSE score ≥ 26 points had a mortality percentage of 17% per annual year in the second year after baseline, while centenarians with a baseline MMSE score < 26 points had a mortality of 42% per annual year (p = 0.003). The cohort was 2.1-fold enriched with the neuroprotective APOE-ε2 allele relative to 60-80 year-old population controls (p = 4.8 × 10-7), APOE-ε3 was unchanged and the APOE-ε4 allele was 2.3-fold depleted (p = 6.3 × 10-7). Comprehensive characterization of the 100-plus cohort of cognitively healthy centenarians might reveal protective factors that explain the physiology of long-term preserved cognitive health.

U2 - 10.1007/s10654-018-0451-3

DO - 10.1007/s10654-018-0451-3

M3 - Article

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

ER -