The anti-parkinsonian drug amantadine inhibits the N-methyl-D-aspartic acid-evoked release of acetylcholine from rat neostriatum in a non-competitive way

J C Stoof, J Booij, B Drukarch, E C Wolters

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The anti-viral drug amantadine is used in the treatment of Parkinson's disease without the drug having a well established mechanism of action. Amantadine is reported to displace the non-competitive NMDA receptor antagonist MK-801 from its binding site in the central nervous system. We show that amantadine inhibits, in a non-competitive way, the NMDA receptor-mediated stimulation of acetylcholine release from rat neostriatum in vitro in 'therapeutic' (i.e. low micromolar range) concentrations. Moreover, contrary to previous reports, amantadine, in this concentration range, did not affect the in vitro release of dopamine from neostriatal tissue.

Original languageEnglish
Pages (from-to)439-43
Number of pages5
JournalEuropean Journal of Pharmacology
Volume213
Issue number3
Publication statusPublished - 31 Mar 1992

Cite this

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title = "The anti-parkinsonian drug amantadine inhibits the N-methyl-D-aspartic acid-evoked release of acetylcholine from rat neostriatum in a non-competitive way",
abstract = "The anti-viral drug amantadine is used in the treatment of Parkinson's disease without the drug having a well established mechanism of action. Amantadine is reported to displace the non-competitive NMDA receptor antagonist MK-801 from its binding site in the central nervous system. We show that amantadine inhibits, in a non-competitive way, the NMDA receptor-mediated stimulation of acetylcholine release from rat neostriatum in vitro in 'therapeutic' (i.e. low micromolar range) concentrations. Moreover, contrary to previous reports, amantadine, in this concentration range, did not affect the in vitro release of dopamine from neostriatal tissue.",
keywords = "Acetylcholine, Amantadine, Animals, Antiparkinson Agents, Binding, Competitive, Corpus Striatum, Dopamine, Male, N-Methylaspartate, Rats, Rats, Inbred Strains, Journal Article",
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year = "1992",
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journal = "European Journal of Pharmacology",
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The anti-parkinsonian drug amantadine inhibits the N-methyl-D-aspartic acid-evoked release of acetylcholine from rat neostriatum in a non-competitive way. / Stoof, J C; Booij, J; Drukarch, B; Wolters, E C.

In: European Journal of Pharmacology, Vol. 213, No. 3, 31.03.1992, p. 439-43.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The anti-parkinsonian drug amantadine inhibits the N-methyl-D-aspartic acid-evoked release of acetylcholine from rat neostriatum in a non-competitive way

AU - Stoof, J C

AU - Booij, J

AU - Drukarch, B

AU - Wolters, E C

PY - 1992/3/31

Y1 - 1992/3/31

N2 - The anti-viral drug amantadine is used in the treatment of Parkinson's disease without the drug having a well established mechanism of action. Amantadine is reported to displace the non-competitive NMDA receptor antagonist MK-801 from its binding site in the central nervous system. We show that amantadine inhibits, in a non-competitive way, the NMDA receptor-mediated stimulation of acetylcholine release from rat neostriatum in vitro in 'therapeutic' (i.e. low micromolar range) concentrations. Moreover, contrary to previous reports, amantadine, in this concentration range, did not affect the in vitro release of dopamine from neostriatal tissue.

AB - The anti-viral drug amantadine is used in the treatment of Parkinson's disease without the drug having a well established mechanism of action. Amantadine is reported to displace the non-competitive NMDA receptor antagonist MK-801 from its binding site in the central nervous system. We show that amantadine inhibits, in a non-competitive way, the NMDA receptor-mediated stimulation of acetylcholine release from rat neostriatum in vitro in 'therapeutic' (i.e. low micromolar range) concentrations. Moreover, contrary to previous reports, amantadine, in this concentration range, did not affect the in vitro release of dopamine from neostriatal tissue.

KW - Acetylcholine

KW - Amantadine

KW - Animals

KW - Antiparkinson Agents

KW - Binding, Competitive

KW - Corpus Striatum

KW - Dopamine

KW - Male

KW - N-Methylaspartate

KW - Rats

KW - Rats, Inbred Strains

KW - Journal Article

M3 - Article

VL - 213

SP - 439

EP - 443

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

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ER -