The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes

B Drukarch, J Flier, C A M Jongenelen, G Andringa, A N M Schoffelmeer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Anethole dithiolethione (ADT) is a clinically available, pluripotent antioxidant proposed as a neuroprotectant for Parkinson's disease (PD). Here, using extracts from cultured astrocytes, containing both monoamine oxidase (MAO) A and B activity, we demonstrate that ADT concentration-dependently inhibits MAO-B activity in a clinically relevant concentration range (0.03-30 microM, IC-50 = 0.5 microM) without affecting MAO A activity. Considering the alleged contribution of MAO activity in general, and MAO-B in particular, to oxidative stress and neurodegeneration in PD, our data further support the neuroprotective potential of ADT.

Original languageEnglish
Pages (from-to)593-8
Number of pages6
JournalJournal of Neural Transmission
Volume113
Issue number5
DOIs
Publication statusPublished - May 2006

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