The art of quality assessment of RCTs included in systematic reviews

Arianne P. Verhagen*, Henrica C.W. De Vet, Robert A. De Bie, Maarten Boers, Piet A. Van Den Brandt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The best evidence on the efficacy of medical interventions is provided by high-quality trials summarized in high-quality systematic reviews or meta-analyses. The methodological quality of studies included in a systematic review can have a substantial impact on the estimates of the treatment effect and therefore on the conclusions of such a review. But what is the empirical evidence to support quality assessment of randomized clinical trials (RCTs)? We elaborate on questions such as: what is the concept of quality of individual studies (RCTs), can quality be measured validly and reliably? Plans for future research on this issue are proposed.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalJournal of Clinical Epidemiology
Volume54
Issue number7
DOIs
Publication statusPublished - 1 Jan 2001

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