The association between age and bone mineral density in men and women aged 55 years and over: the Rotterdam Study

H Burger, P L van Daele, D Algra, F A van den Ouweland, D E Grobbee, A Hofman, C van Kuijk, H E Schütte, J C Birkenhäger, H A Pols

Research output: Contribution to journalArticleAcademicpeer-review


In this cross-sectional study, bone mineral density (BMD) measurements were performed in 1762 ambulatory subjects (678 men and 1084 women) aged 55 years and over from the Rotterdam Study, a population based study of diseases in the elderly. BMD measurements of the proximal femur and lumbar spine were performed using dual energy X-ray absorptiometry. No age-related decline in BMD could be observed in the lumbar spine. Yearly percentage BMD reduction in women and men was -0.6% and -0.3% in the femoral neck, -0.8% and -0.5% in the Ward's triangle, and -0.4% and -0.3% in the trochanter, respectively. Late menopause was associated with high BMD in Ward's triangle and lumbar spine. We conclude that: (1) accurate assessment of age-related bone reduction in the spine is impossible from cross-sectional studies since BMD measurements in the elderly may be influenced by spinal osteoarthritis; and (2) the rate of age-related bone reduction in the femoral neck appears to be approximately two times higher in women than in men.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Bone and Mineral Research
Issue number1
Publication statusPublished - Apr 1994

Cite this