The association between social jetlag, the metabolic syndrome and type 2 diabetes in a 40+year old population: the New Hoorn study

F Rutters, A D Koopman, S P Rauh, E Van't Riet, L Groeneveld, A Van Der Linden, J W Beulens, P J Elders, J M Dekker, G Nijpels

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background and aims: Social jetlag is the discrepancy between our internal circadian clock and social clock and is a measure of circadian misalignment. Previous studies have shown that up to two thirds of the general population, aged 18-35y, suffer from social jetlag and its negative effects on metabolic parameters. As data from the general population over 40+y is missing, the aim of this study is to examine the prevalence of social jetlag and the association between social jetlag, the metabolic syndrome and type 2 diabetes in a 40+yearold, population-based cohort. Materials and methods: We used cross-sectional data from the New Hoorn study cohort, n=1734, 48% male, aged 45-73y. Social jetlag was measured using a questionnaire, calculated as the difference in mid-point sleep on week and weekend days and defined as 0-1h, 1-2h or >2h social jetlag.Metabolic syndrome was defined according to the Adult Treatment Panel III, including waist circumference, hypertension and levels of fasting plasma glucose, HDL-C and triglycerides. Pre-diabetes and Type 2 diabetes were defined according to the WHO guidelines; glucose levels > 6.1 mmol/l, HbA1c > 6% or use of diabetes medication. Results: In our 40+year-old population-based cohort, we observed that only 15% of the unemployed/retired participants had social jetlag of >1h and 65% of the employed participants. In the unemployed/retired group no significant associations were observed between social jetlag status, (parameters of) metabolic syndrome and (pre-)diabetes. However, in the employed group, logistic regression adjusted for age, sex and sleep duration showed a positive association between social jetlag, metabolic syndrome and (pre-)diabetes, with respectively OR 1.1 (95%CI 0.7-1.7) and OR 1.7 (95%CI 1.2-2.4) for participants with 1-2h social jetlag, as well as OR 2.1 (95%CI 1.2-3.6) and OR 2.3 (95%CI 1.5-3.8) for >2h of social jetlag, when compared to participants with 0-1h social jetlag. Conclusion: Social jetlag is associated with metabolic syndrome and (pre-)diabetes in working, 40+year-old participants.
Original languageEnglish
Pages (from-to)S183
JournalDiabetologia
Volume59 (1 Supp
DOIs
Publication statusPublished - 2016

Cite this

@article{bfa832ea4d6348edb98039fddb3d325e,
title = "The association between social jetlag, the metabolic syndrome and type 2 diabetes in a 40+year old population: the New Hoorn study",
abstract = "Background and aims: Social jetlag is the discrepancy between our internal circadian clock and social clock and is a measure of circadian misalignment. Previous studies have shown that up to two thirds of the general population, aged 18-35y, suffer from social jetlag and its negative effects on metabolic parameters. As data from the general population over 40+y is missing, the aim of this study is to examine the prevalence of social jetlag and the association between social jetlag, the metabolic syndrome and type 2 diabetes in a 40+yearold, population-based cohort. Materials and methods: We used cross-sectional data from the New Hoorn study cohort, n=1734, 48{\%} male, aged 45-73y. Social jetlag was measured using a questionnaire, calculated as the difference in mid-point sleep on week and weekend days and defined as 0-1h, 1-2h or >2h social jetlag.Metabolic syndrome was defined according to the Adult Treatment Panel III, including waist circumference, hypertension and levels of fasting plasma glucose, HDL-C and triglycerides. Pre-diabetes and Type 2 diabetes were defined according to the WHO guidelines; glucose levels > 6.1 mmol/l, HbA1c > 6{\%} or use of diabetes medication. Results: In our 40+year-old population-based cohort, we observed that only 15{\%} of the unemployed/retired participants had social jetlag of >1h and 65{\%} of the employed participants. In the unemployed/retired group no significant associations were observed between social jetlag status, (parameters of) metabolic syndrome and (pre-)diabetes. However, in the employed group, logistic regression adjusted for age, sex and sleep duration showed a positive association between social jetlag, metabolic syndrome and (pre-)diabetes, with respectively OR 1.1 (95{\%}CI 0.7-1.7) and OR 1.7 (95{\%}CI 1.2-2.4) for participants with 1-2h social jetlag, as well as OR 2.1 (95{\%}CI 1.2-3.6) and OR 2.3 (95{\%}CI 1.5-3.8) for >2h of social jetlag, when compared to participants with 0-1h social jetlag. Conclusion: Social jetlag is associated with metabolic syndrome and (pre-)diabetes in working, 40+year-old participants.",
author = "F Rutters and Koopman, {A D} and Rauh, {S P} and {Van't Riet}, E and L Groeneveld and {Van Der Linden}, A and Beulens, {J W} and Elders, {P J} and Dekker, {J M} and G Nijpels",
year = "2016",
doi = "10.1007/s00125-016-4046-9",
language = "English",
volume = "59 (1 Supp",
pages = "S183",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer Verlag",

}

The association between social jetlag, the metabolic syndrome and type 2 diabetes in a 40+year old population: the New Hoorn study. / Rutters, F; Koopman, A D; Rauh, S P; Van't Riet, E; Groeneveld, L; Van Der Linden, A; Beulens, J W; Elders, P J; Dekker, J M; Nijpels, G.

In: Diabetologia, Vol. 59 (1 Supp, 2016, p. S183.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The association between social jetlag, the metabolic syndrome and type 2 diabetes in a 40+year old population: the New Hoorn study

AU - Rutters, F

AU - Koopman, A D

AU - Rauh, S P

AU - Van't Riet, E

AU - Groeneveld, L

AU - Van Der Linden, A

AU - Beulens, J W

AU - Elders, P J

AU - Dekker, J M

AU - Nijpels, G

PY - 2016

Y1 - 2016

N2 - Background and aims: Social jetlag is the discrepancy between our internal circadian clock and social clock and is a measure of circadian misalignment. Previous studies have shown that up to two thirds of the general population, aged 18-35y, suffer from social jetlag and its negative effects on metabolic parameters. As data from the general population over 40+y is missing, the aim of this study is to examine the prevalence of social jetlag and the association between social jetlag, the metabolic syndrome and type 2 diabetes in a 40+yearold, population-based cohort. Materials and methods: We used cross-sectional data from the New Hoorn study cohort, n=1734, 48% male, aged 45-73y. Social jetlag was measured using a questionnaire, calculated as the difference in mid-point sleep on week and weekend days and defined as 0-1h, 1-2h or >2h social jetlag.Metabolic syndrome was defined according to the Adult Treatment Panel III, including waist circumference, hypertension and levels of fasting plasma glucose, HDL-C and triglycerides. Pre-diabetes and Type 2 diabetes were defined according to the WHO guidelines; glucose levels > 6.1 mmol/l, HbA1c > 6% or use of diabetes medication. Results: In our 40+year-old population-based cohort, we observed that only 15% of the unemployed/retired participants had social jetlag of >1h and 65% of the employed participants. In the unemployed/retired group no significant associations were observed between social jetlag status, (parameters of) metabolic syndrome and (pre-)diabetes. However, in the employed group, logistic regression adjusted for age, sex and sleep duration showed a positive association between social jetlag, metabolic syndrome and (pre-)diabetes, with respectively OR 1.1 (95%CI 0.7-1.7) and OR 1.7 (95%CI 1.2-2.4) for participants with 1-2h social jetlag, as well as OR 2.1 (95%CI 1.2-3.6) and OR 2.3 (95%CI 1.5-3.8) for >2h of social jetlag, when compared to participants with 0-1h social jetlag. Conclusion: Social jetlag is associated with metabolic syndrome and (pre-)diabetes in working, 40+year-old participants.

AB - Background and aims: Social jetlag is the discrepancy between our internal circadian clock and social clock and is a measure of circadian misalignment. Previous studies have shown that up to two thirds of the general population, aged 18-35y, suffer from social jetlag and its negative effects on metabolic parameters. As data from the general population over 40+y is missing, the aim of this study is to examine the prevalence of social jetlag and the association between social jetlag, the metabolic syndrome and type 2 diabetes in a 40+yearold, population-based cohort. Materials and methods: We used cross-sectional data from the New Hoorn study cohort, n=1734, 48% male, aged 45-73y. Social jetlag was measured using a questionnaire, calculated as the difference in mid-point sleep on week and weekend days and defined as 0-1h, 1-2h or >2h social jetlag.Metabolic syndrome was defined according to the Adult Treatment Panel III, including waist circumference, hypertension and levels of fasting plasma glucose, HDL-C and triglycerides. Pre-diabetes and Type 2 diabetes were defined according to the WHO guidelines; glucose levels > 6.1 mmol/l, HbA1c > 6% or use of diabetes medication. Results: In our 40+year-old population-based cohort, we observed that only 15% of the unemployed/retired participants had social jetlag of >1h and 65% of the employed participants. In the unemployed/retired group no significant associations were observed between social jetlag status, (parameters of) metabolic syndrome and (pre-)diabetes. However, in the employed group, logistic regression adjusted for age, sex and sleep duration showed a positive association between social jetlag, metabolic syndrome and (pre-)diabetes, with respectively OR 1.1 (95%CI 0.7-1.7) and OR 1.7 (95%CI 1.2-2.4) for participants with 1-2h social jetlag, as well as OR 2.1 (95%CI 1.2-3.6) and OR 2.3 (95%CI 1.5-3.8) for >2h of social jetlag, when compared to participants with 0-1h social jetlag. Conclusion: Social jetlag is associated with metabolic syndrome and (pre-)diabetes in working, 40+year-old participants.

U2 - 10.1007/s00125-016-4046-9

DO - 10.1007/s00125-016-4046-9

M3 - Article

VL - 59 (1 Supp

SP - S183

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

ER -