The correlations between IL-17 vs. Th17 cells and cancer patient survival: A systematic review

Simone Punt, Jessica M. Langenhoff, H. Putter, Gert Jan Fleuren, Arko Gorter, Ekaterina S. Jordanova*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+ cells.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
Issue number2
Publication statusPublished - 2015

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