The course of sexual interest and enjoyment in head and neck cancer patients treated with primary (chemo)radiotherapy

H. C. Melissant, F. Jansen, L. E.R. Schutte, B. I. Lissenberg-Witte, J. Buter, C. R. Leemans, M. A. Sprangers, M. R. Vergeer, E. T.M. Laan, I. M. Verdonck-de Leeuw

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: The aim of this prospective study was to investigate the course of sexual interest and enjoyment in relation to sociodemographic and clinical factors, health-related quality of life (HRQOL), and symptoms of psychological distress in head and neck cancer (HNC) patients treated with primary (chemo)radiotherapy. Methods: HNC patients (n = 354) completed patient-reported outcome measures (PROMs) on HRQOL (EORTC QLQ-C30 and QLQ-H&N35, including the sexuality subscale covering less sexual interest and enjoyment), and psychological distress (HADS) pretreatment, at 6-week follow-up and at 3-, 6-, 12-, 18-, and 24-month follow-up (i.e., after treatment). Linear mixed models were used to analyze the course of sexuality from pretreatment to 24-month follow-up, and to investigate its relation to sociodemographic and clinical factors, HRQOL, and psychological distress as measured at baseline, and to investigate the course of sexuality from 6- to 24-month follow-up in relation to these factors measured at 6-month follow-up. Results: Before start of treatment, 37% of patients reported having less sexuality, which increased to 60% at 6-week follow-up, and returned to baseline level from 12-month follow-up onwards. Older age (p = 0.037) and trouble with social contact (p < 0.001), weight loss (p = 0.013), and constipation (p = 0.041) before treatment were associated with less sexuality over time. Female gender (p = 0.021) and poor social functioning (p < 0.001) at 6-month follow-up were associated with less sexuality from 6- to 24-month follow-up. Discussion: Less sexuality is often reported in HNC patients treated with (chemo)radiotherapy. Using PROMs in clinical practice may help identify patients who might benefit from supportive care targeting sexuality.

LanguageEnglish
Pages120-126
Number of pages7
JournalOral Oncology
Volume83
DOIs
Publication statusPublished - 1 Aug 2018

Cite this

@article{b944318f509a473184a1e08e4ed316b2,
title = "The course of sexual interest and enjoyment in head and neck cancer patients treated with primary (chemo)radiotherapy",
abstract = "Introduction: The aim of this prospective study was to investigate the course of sexual interest and enjoyment in relation to sociodemographic and clinical factors, health-related quality of life (HRQOL), and symptoms of psychological distress in head and neck cancer (HNC) patients treated with primary (chemo)radiotherapy. Methods: HNC patients (n = 354) completed patient-reported outcome measures (PROMs) on HRQOL (EORTC QLQ-C30 and QLQ-H&N35, including the sexuality subscale covering less sexual interest and enjoyment), and psychological distress (HADS) pretreatment, at 6-week follow-up and at 3-, 6-, 12-, 18-, and 24-month follow-up (i.e., after treatment). Linear mixed models were used to analyze the course of sexuality from pretreatment to 24-month follow-up, and to investigate its relation to sociodemographic and clinical factors, HRQOL, and psychological distress as measured at baseline, and to investigate the course of sexuality from 6- to 24-month follow-up in relation to these factors measured at 6-month follow-up. Results: Before start of treatment, 37{\%} of patients reported having less sexuality, which increased to 60{\%} at 6-week follow-up, and returned to baseline level from 12-month follow-up onwards. Older age (p = 0.037) and trouble with social contact (p < 0.001), weight loss (p = 0.013), and constipation (p = 0.041) before treatment were associated with less sexuality over time. Female gender (p = 0.021) and poor social functioning (p < 0.001) at 6-month follow-up were associated with less sexuality from 6- to 24-month follow-up. Discussion: Less sexuality is often reported in HNC patients treated with (chemo)radiotherapy. Using PROMs in clinical practice may help identify patients who might benefit from supportive care targeting sexuality.",
keywords = "Chemotherapy, Head and Neck Cancer, Longitudinal, Oncology, Patient-Reported Outcome Measures, Psychology, Quality of Life, Radiotherapy, Sexual Interest, Sexuality",
author = "Melissant, {H. C.} and F. Jansen and Schutte, {L. E.R.} and Lissenberg-Witte, {B. I.} and J. Buter and Leemans, {C. R.} and Sprangers, {M. A.} and Vergeer, {M. R.} and Laan, {E. T.M.} and {Verdonck-de Leeuw}, {I. M.}",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.oraloncology.2018.06.016",
language = "English",
volume = "83",
pages = "120--126",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",

}

The course of sexual interest and enjoyment in head and neck cancer patients treated with primary (chemo)radiotherapy. / Melissant, H. C.; Jansen, F.; Schutte, L. E.R.; Lissenberg-Witte, B. I.; Buter, J.; Leemans, C. R.; Sprangers, M. A.; Vergeer, M. R.; Laan, E. T.M.; Verdonck-de Leeuw, I. M.

In: Oral Oncology, Vol. 83, 01.08.2018, p. 120-126.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The course of sexual interest and enjoyment in head and neck cancer patients treated with primary (chemo)radiotherapy

AU - Melissant, H. C.

AU - Jansen, F.

AU - Schutte, L. E.R.

AU - Lissenberg-Witte, B. I.

AU - Buter, J.

AU - Leemans, C. R.

AU - Sprangers, M. A.

AU - Vergeer, M. R.

AU - Laan, E. T.M.

AU - Verdonck-de Leeuw, I. M.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Introduction: The aim of this prospective study was to investigate the course of sexual interest and enjoyment in relation to sociodemographic and clinical factors, health-related quality of life (HRQOL), and symptoms of psychological distress in head and neck cancer (HNC) patients treated with primary (chemo)radiotherapy. Methods: HNC patients (n = 354) completed patient-reported outcome measures (PROMs) on HRQOL (EORTC QLQ-C30 and QLQ-H&N35, including the sexuality subscale covering less sexual interest and enjoyment), and psychological distress (HADS) pretreatment, at 6-week follow-up and at 3-, 6-, 12-, 18-, and 24-month follow-up (i.e., after treatment). Linear mixed models were used to analyze the course of sexuality from pretreatment to 24-month follow-up, and to investigate its relation to sociodemographic and clinical factors, HRQOL, and psychological distress as measured at baseline, and to investigate the course of sexuality from 6- to 24-month follow-up in relation to these factors measured at 6-month follow-up. Results: Before start of treatment, 37% of patients reported having less sexuality, which increased to 60% at 6-week follow-up, and returned to baseline level from 12-month follow-up onwards. Older age (p = 0.037) and trouble with social contact (p < 0.001), weight loss (p = 0.013), and constipation (p = 0.041) before treatment were associated with less sexuality over time. Female gender (p = 0.021) and poor social functioning (p < 0.001) at 6-month follow-up were associated with less sexuality from 6- to 24-month follow-up. Discussion: Less sexuality is often reported in HNC patients treated with (chemo)radiotherapy. Using PROMs in clinical practice may help identify patients who might benefit from supportive care targeting sexuality.

AB - Introduction: The aim of this prospective study was to investigate the course of sexual interest and enjoyment in relation to sociodemographic and clinical factors, health-related quality of life (HRQOL), and symptoms of psychological distress in head and neck cancer (HNC) patients treated with primary (chemo)radiotherapy. Methods: HNC patients (n = 354) completed patient-reported outcome measures (PROMs) on HRQOL (EORTC QLQ-C30 and QLQ-H&N35, including the sexuality subscale covering less sexual interest and enjoyment), and psychological distress (HADS) pretreatment, at 6-week follow-up and at 3-, 6-, 12-, 18-, and 24-month follow-up (i.e., after treatment). Linear mixed models were used to analyze the course of sexuality from pretreatment to 24-month follow-up, and to investigate its relation to sociodemographic and clinical factors, HRQOL, and psychological distress as measured at baseline, and to investigate the course of sexuality from 6- to 24-month follow-up in relation to these factors measured at 6-month follow-up. Results: Before start of treatment, 37% of patients reported having less sexuality, which increased to 60% at 6-week follow-up, and returned to baseline level from 12-month follow-up onwards. Older age (p = 0.037) and trouble with social contact (p < 0.001), weight loss (p = 0.013), and constipation (p = 0.041) before treatment were associated with less sexuality over time. Female gender (p = 0.021) and poor social functioning (p < 0.001) at 6-month follow-up were associated with less sexuality from 6- to 24-month follow-up. Discussion: Less sexuality is often reported in HNC patients treated with (chemo)radiotherapy. Using PROMs in clinical practice may help identify patients who might benefit from supportive care targeting sexuality.

KW - Chemotherapy

KW - Head and Neck Cancer

KW - Longitudinal

KW - Oncology

KW - Patient-Reported Outcome Measures

KW - Psychology

KW - Quality of Life

KW - Radiotherapy

KW - Sexual Interest

KW - Sexuality

UR - http://www.scopus.com/inward/record.url?scp=85048895825&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2018.06.016

DO - 10.1016/j.oraloncology.2018.06.016

M3 - Article

VL - 83

SP - 120

EP - 126

JO - Oral Oncology

T2 - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

ER -