The development of D antibodies after D-mismatched kidney transplantation in a setting of reduced immunosuppression

Thomas H. P. M. Habets, Joris Vanderlocht, Ron J. M. H. E. Straat, Tim C. van Smaalen, Gerard M. J. Bos, Erik A. Beckers, Maarten H. L. Christiaans, Yvonne M. C. Henskens

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Abstract

BACKGROUND: D antigens are not taken into account in the allocation of solid organs. Female transplant recipients with D antibodies as a consequence of D-mismatched kidney transplantation may develop hemolytic disease of the fetus and newborn in future pregnancies. We examined D antibody development in transplant recipients who received D-mismatched kidney transplantation in absence of D prophylaxis and in a setting of reduced immunosuppression. STUDY DESIGN AND METHODS: From 1993 until 2015, a total of 1355 kidney patients received transplantations in our center of whom 156 received a D-mismatched graft. A retrospective analysis was conducted; frozen stored sera obtained from transplant recipients 3 months after transplantation were tested for irregular red blood cell (RBC) antibodies using a three-cell screening and an identification panel. In the case of D antibody positivity, additional testing was performed 1 month before transplantation. RESULTS: In seven of 156 (4.5%) transplant recipients we found irregular RBC antibodies after transplantation, of which five (3.2%) were determined to be D antibodies. We observed only one (0.6%) recipient without D antibodies before transplantation. CONCLUSION: Although the risk of D antibody development is considerably lower after D-mismatched kidney transplantation than D-mismatched pregnancy, anti-D prophylaxis may still be advisable for female transplant recipients of childbearing age.
Original languageEnglish
Pages (from-to)100-104
JournalTransfusion
Volume58
Issue number1
DOIs
Publication statusPublished - 2018
Externally publishedYes

Cite this

Habets, T. H. P. M., Vanderlocht, J., Straat, R. J. M. H. E., van Smaalen, T. C., Bos, G. M. J., Beckers, E. A., ... Henskens, Y. M. C. (2018). The development of D antibodies after D-mismatched kidney transplantation in a setting of reduced immunosuppression. Transfusion, 58(1), 100-104. https://doi.org/10.1111/trf.14405