The effect of APOE genotype on clinical phenotype in Alzheimer disease

W. M. Van Der Flier; S. N.M. Schoonenboom; Y. A.L. Pijnenburg; N. C. Fox; P. Scheltens

doi:10.1212/01.wnl.0000228222.17111.2a

The effect of APOE genotype on clinical phenotype in Alzheimer disease

W. M. Van Der Flier^*, S. N.M. Schoonenboom, Y. A.L. Pijnenburg, N. C. Fox, P. Scheltens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-ε4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-ε4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-ε4 allele.

Original language	English
Pages (from-to)	526-527
Number of pages	2
Journal	Neurology
Volume	67
Issue number	3
DOIs	https://doi.org/10.1212/01.wnl.0000228222.17111.2a
Publication status	Published - 1 Aug 2006

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AU - Fox, N. C.

AU - Scheltens, P.

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AB - The authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-ε4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-ε4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-ε4 allele.

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The effect of APOE genotype on clinical phenotype in Alzheimer disease

Abstract

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