Abstract
The authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-ε4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-ε4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-ε4 allele.
Original language | English |
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Pages (from-to) | 526-527 |
Number of pages | 2 |
Journal | Neurology |
Volume | 67 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Aug 2006 |