The effect of cycloleucine on SFV A7(74) infection in mice

S Amor, H E Webb

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cycloleucine (CL), a non-metabolizable amino acid analogue, was found to reduce thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice. The maximum effects were seen when three daily doses of CL were given to mice 24 h after an SFV A7(74) infection. In these mice thymus atrophy led to abolition of thymus dependent immune responses and changes in the pathological features of the viral infection--the most striking feature being prevention of demyelination. In addition virus titres in the brains of CL treated infected mice were increased and prolonged. These results show that demyelination following an SFV A7(74) infection is not a result of direct virus action, but of a T-cell mediated mechanism.

Original languageEnglish
Pages (from-to)225-35
Number of pages11
JournalInternational Journal of Experimental Pathology
Volume68
Issue number2
Publication statusPublished - Apr 1987

Cite this

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title = "The effect of cycloleucine on SFV A7(74) infection in mice",
abstract = "Cycloleucine (CL), a non-metabolizable amino acid analogue, was found to reduce thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice. The maximum effects were seen when three daily doses of CL were given to mice 24 h after an SFV A7(74) infection. In these mice thymus atrophy led to abolition of thymus dependent immune responses and changes in the pathological features of the viral infection--the most striking feature being prevention of demyelination. In addition virus titres in the brains of CL treated infected mice were increased and prolonged. These results show that demyelination following an SFV A7(74) infection is not a result of direct virus action, but of a T-cell mediated mechanism.",
keywords = "Amino Acids, Animals, Antibodies, Viral, Brain, Cycloleucine, Demyelinating Diseases, Dose-Response Relationship, Drug, Immunoglobulin M, Immunosuppressive Agents, Mice, Mice, Inbred Strains, Organ Size, Semliki forest virus, Spleen, Thymus Gland, Togaviridae Infections, Journal Article, Research Support, Non-U.S. Gov't",
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pages = "225--35",
journal = "International Journal of Experimental Pathology",
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The effect of cycloleucine on SFV A7(74) infection in mice. / Amor, S; Webb, H E.

In: International Journal of Experimental Pathology, Vol. 68, No. 2, 04.1987, p. 225-35.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The effect of cycloleucine on SFV A7(74) infection in mice

AU - Amor, S

AU - Webb, H E

PY - 1987/4

Y1 - 1987/4

N2 - Cycloleucine (CL), a non-metabolizable amino acid analogue, was found to reduce thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice. The maximum effects were seen when three daily doses of CL were given to mice 24 h after an SFV A7(74) infection. In these mice thymus atrophy led to abolition of thymus dependent immune responses and changes in the pathological features of the viral infection--the most striking feature being prevention of demyelination. In addition virus titres in the brains of CL treated infected mice were increased and prolonged. These results show that demyelination following an SFV A7(74) infection is not a result of direct virus action, but of a T-cell mediated mechanism.

AB - Cycloleucine (CL), a non-metabolizable amino acid analogue, was found to reduce thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice. The maximum effects were seen when three daily doses of CL were given to mice 24 h after an SFV A7(74) infection. In these mice thymus atrophy led to abolition of thymus dependent immune responses and changes in the pathological features of the viral infection--the most striking feature being prevention of demyelination. In addition virus titres in the brains of CL treated infected mice were increased and prolonged. These results show that demyelination following an SFV A7(74) infection is not a result of direct virus action, but of a T-cell mediated mechanism.

KW - Amino Acids

KW - Animals

KW - Antibodies, Viral

KW - Brain

KW - Cycloleucine

KW - Demyelinating Diseases

KW - Dose-Response Relationship, Drug

KW - Immunoglobulin M

KW - Immunosuppressive Agents

KW - Mice

KW - Mice, Inbred Strains

KW - Organ Size

KW - Semliki forest virus

KW - Spleen

KW - Thymus Gland

KW - Togaviridae Infections

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

VL - 68

SP - 225

EP - 235

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

SN - 0959-9673

IS - 2

ER -