The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment

Katharina Brueggen, Michel J Grothe, Martin Dyrba, Andreas Fellgiebel, Florian Fischer, Massimo Filippi, Federica Agosta, Peter Nestor, Eva Meisenzahl, Janusch Blautzik, Lutz Frölich, Lucrezia Hausner, Arun L W Bokde, Giovanni Frisoni, Michela Pievani, Stefan Klöppel, David Prvulovic, Frederik Barkhof, Petra J W Pouwels, Johannes Schröder & 3 others Harald Hampel, Karlheinz Hauenstein, Stefan Teipel

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalNeuroImage
Volume144
Issue numberPt B
DOIs
Publication statusPublished - Jan 2017

Cite this

Brueggen, K., Grothe, M. J., Dyrba, M., Fellgiebel, A., Fischer, F., Filippi, M., ... Teipel, S. (2017). The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment. NeuroImage, 144(Pt B), 305-308. https://doi.org/10.1016/j.neuroimage.2016.03.067
Brueggen, Katharina ; Grothe, Michel J ; Dyrba, Martin ; Fellgiebel, Andreas ; Fischer, Florian ; Filippi, Massimo ; Agosta, Federica ; Nestor, Peter ; Meisenzahl, Eva ; Blautzik, Janusch ; Frölich, Lutz ; Hausner, Lucrezia ; Bokde, Arun L W ; Frisoni, Giovanni ; Pievani, Michela ; Klöppel, Stefan ; Prvulovic, David ; Barkhof, Frederik ; Pouwels, Petra J W ; Schröder, Johannes ; Hampel, Harald ; Hauenstein, Karlheinz ; Teipel, Stefan. / The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment. In: NeuroImage. 2017 ; Vol. 144, No. Pt B. pp. 305-308.
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abstract = "The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.",
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Brueggen, K, Grothe, MJ, Dyrba, M, Fellgiebel, A, Fischer, F, Filippi, M, Agosta, F, Nestor, P, Meisenzahl, E, Blautzik, J, Frölich, L, Hausner, L, Bokde, ALW, Frisoni, G, Pievani, M, Klöppel, S, Prvulovic, D, Barkhof, F, Pouwels, PJW, Schröder, J, Hampel, H, Hauenstein, K & Teipel, S 2017, 'The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment' NeuroImage, vol. 144, no. Pt B, pp. 305-308. https://doi.org/10.1016/j.neuroimage.2016.03.067

The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment. / Brueggen, Katharina; Grothe, Michel J; Dyrba, Martin; Fellgiebel, Andreas; Fischer, Florian; Filippi, Massimo; Agosta, Federica; Nestor, Peter; Meisenzahl, Eva; Blautzik, Janusch; Frölich, Lutz; Hausner, Lucrezia; Bokde, Arun L W; Frisoni, Giovanni; Pievani, Michela; Klöppel, Stefan; Prvulovic, David; Barkhof, Frederik; Pouwels, Petra J W; Schröder, Johannes; Hampel, Harald; Hauenstein, Karlheinz; Teipel, Stefan.

In: NeuroImage, Vol. 144, No. Pt B, 01.2017, p. 305-308.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Brueggen, Katharina

AU - Grothe, Michel J

AU - Dyrba, Martin

AU - Fellgiebel, Andreas

AU - Fischer, Florian

AU - Filippi, Massimo

AU - Agosta, Federica

AU - Nestor, Peter

AU - Meisenzahl, Eva

AU - Blautzik, Janusch

AU - Frölich, Lutz

AU - Hausner, Lucrezia

AU - Bokde, Arun L W

AU - Frisoni, Giovanni

AU - Pievani, Michela

AU - Klöppel, Stefan

AU - Prvulovic, David

AU - Barkhof, Frederik

AU - Pouwels, Petra J W

AU - Schröder, Johannes

AU - Hampel, Harald

AU - Hauenstein, Karlheinz

AU - Teipel, Stefan

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2017/1

Y1 - 2017/1

N2 - The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.

AB - The European DTI Study on Dementia (EDSD) is a multicenter framework created to study the diagnostic accuracy and inter-site variability of DTI-derived markers in patients with manifest and prodromal Alzheimer's disease (AD). The dynamically growing database presently includes 493 DTI, 512 T1-weighted MRI, and 300 FLAIR scans from patients with AD dementia, patients with Mild Cognitive Impairment (MCI) and matched Healthy Controls, acquired on 13 different scanner platforms. The imaging data is publicly available, along with the subjects' demographic and clinical characterization. Detailed neuropsychological information, cerebrospinal fluid information on biomarkers and clinical follow-up diagnoses are included for a subset of subjects. This paper describes the rationale and structure of the EDSD, summarizes the available data, and explains how to gain access to the database. The EDSD is a useful database for researchers seeking to investigate the contribution of DTI to dementia diagnostics.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Cognitive Dysfunction

KW - Databases, Factual

KW - Diffusion Tensor Imaging

KW - Female

KW - Humans

KW - Information Dissemination

KW - Male

KW - Middle Aged

KW - Journal Article

KW - Multicenter Study

U2 - 10.1016/j.neuroimage.2016.03.067

DO - 10.1016/j.neuroimage.2016.03.067

M3 - Article

VL - 144

SP - 305

EP - 308

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - Pt B

ER -