TY - JOUR
T1 - The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
AU - Bos, Isabelle
AU - Vos, Stephanie J.
AU - Frölich, Lutz
AU - Kornhuber, Johannes
AU - Wiltfang, Jens
AU - Maier, Wolfgang
AU - Peters, Oliver
AU - Rüther, Eckhart
AU - Engelborghs, Sebastiaan
AU - Niemantsverdriet, Ellis
AU - De Roeck, Ellen Elisa
AU - Tsolaki, Magda
AU - Freund-Levi, Yvonne
AU - Johannsen, Peter
AU - Vandenberghe, Rik
AU - Lleó, Alberto
AU - Alcolea, Daniel
AU - Frisoni, Giovanni B.
AU - Galluzzi, Samantha
AU - Nobili, Flavio
AU - Morbelli, Silvia
AU - Drzezga, Alexander
AU - Didic, Mira
AU - van Berckel, Bart N.
AU - Salmon, Eric
AU - Bastin, Christine
AU - Dauby, Solene
AU - Santana, Isabel
AU - Baldeiras, Inês
AU - de Mendonça, Alexandre
AU - Silva, Dina
AU - Nordlund, Arto
AU - Coloma, Preciosa M.
AU - Wientzek, Angelika
AU - Alexander, Myriam
AU - Novak, Gerald P.
AU - Gordon, Mark Forrest
AU - Wallin, Åsa K.
AU - Hampel, Harald
AU - Soininen, Hilkka
AU - Herukka, Sanna Kaisa
AU - Scheltens, Philip
AU - Verhey, Frans R.
AU - Visser, Pieter Jelle
AU - Alzheimer's Disease Neuroimaging Initiative
PY - 2017/8/1
Y1 - 2017/8/1
N2 - We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.
AB - We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.
KW - Alzheimer's disease
KW - Biomarkers
KW - IWG-2 criteria
KW - NIA-AA criteria
KW - Prognosis
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85018725939&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2017.03.034
DO - 10.1016/j.neurobiolaging.2017.03.034
M3 - Article
C2 - 28482212
AN - SCOPUS:85018725939
VL - 56
SP - 33
EP - 40
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -