@article{8e4abb67c3ce4a75a4e5f0c96887ec4b,
title = "The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks",
abstract = "Functional connectivity within resting-state networks (RSN-FC) is vital for cognitive functioning. RSN-FC is heritable and partially translates to the anatomic architecture of white matter, but the genetic component of structural connections of RSNs (RSN-SC) and their potential genetic overlap with RSN-FC remain unknown. Here, we perform genome-wide association studies (Ndiscovery = 24,336; Nreplication = 3412) and annotation on RSN-SC and RSN-FC. We identify genes for visual network-SC that are involved in axon guidance and synaptic functioning. Genetic variation in RSN-FC impacts biological processes relevant to brain disorders that previously were only phenotypically associated with RSN-FC alterations. Correlations of the genetic components of RSNs are mostly observed within the functional domain, whereas less overlap is observed within the structural domain and between the functional and structural domains. This study advances the understanding of the complex functional organization of the brain and its structural underpinnings from a genetics viewpoint.",
keywords = "GWAS, connectivity, networks, neuroimaging, resting-state, structure-function",
author = "Elleke Tissink and Josefin Werme and {de Lange}, {Siemon C.} and Savage, {Jeanne E.} and Yongbin Wei and {de Leeuw}, {Christiaan A.} and Mats Nagel and Danielle Posthuma and {van den Heuvel}, {Martijn P.}",
note = "Funding Information: D.P. was supported by The Netherlands Organization for Scientific Research (NWO) Grant VICI 453-14-005, the NWO Gravitation: BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology Grant No. 024.004.012, and the European Research Council (ERC) Advanced Grant No. ERC-2018-AdG GWAS2FUNC 834057. The work of S.C.d.L. was supported by the ZonMw Open Competition Project REMOVE 09120011910032. C.A.d.L. is supported by Hoffman-La Roche. M.P.v.d.H. was supported by NWO VIDI Grant 452-16-015 and the ERC Consolidator of the European Research Council Grant 101001062. J.E.S. was supported by the NWO VENI Grant 201G-064. Publisher Copyright: {\textcopyright} 2023 Tissink et al.",
year = "2023",
month = apr,
day = "1",
doi = "10.1523/ENEURO.0242-22.2023",
language = "English",
volume = "10",
journal = "eNeuro",
issn = "2373-2822",
publisher = "Society for Neuroscience",
number = "4",
}