The greatest kinetochore show on earth

Gerben Vader, Andrea Musacchio

Research output: Contribution to journalArticleAcademicpeer-review


Coordinated chromosome duplication and segregation is key to the existence of every organism on our planet. In eukaryotes, sophisticated protein assemblies called kinetochores are universally required for chromosome segregation, but their protein composition can diverge across the eukaryotic tree of life. In this issue of EMBO Reports, van Hooff et al shed light on kinetochore evolution with a comprehensive study of kinetochore composition across 90 phylogenetically diverse eukaryotes. They show that certain kinetochore complexes have taken distinct evolutionary paths to arrive at a strikingly broad compositional array in present-day eukaryotes, providing exciting new insights into the origins, function, and flexibility of eukaryotic kinetochores.

Original languageEnglish
JournalEMBO Reports
Publication statusAccepted/In press - 1 Jan 2017
Externally publishedYes

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