The expression of the growth associated protein B-50 (GAP-43) is developmentally regulated and reinduced following neuronal injury. Using B-50 as marker for sprouting in single and double immunolabeling of neocortex of Alzheimer's disease (AD) we demonstrate that bulbous B-50 immunoreactive dystrophic neurites are found in β-amyloid/A4 positive plaques. Our results and those of others indicate that dystrophic neurites contain B-50 implicating this protein in the disease induced response.
|Journal||Neuroscience Research Communications|
|Issue number||SUPPL. 1|
|Publication status||Published - 1 Jan 1993|