The hippocampus in multiple sclerosis

Maria A. Rocca, Frederik Barkhof, John De Luca, Jonas Frisén, Jeroen J.G. Geurts, Hanneke E. Hulst, MAGNIMS Study Group

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Some of the clinical manifestations of multiple sclerosis, such as memory impairment and depression, are, at least partly, related to involvement of the hippocampus. Pathological studies have shown extensive demyelination, neuronal damage, and synaptic abnormalities in the hippocampus of patients with multiple sclerosis, and improvements in MRI technology have provided novel ways to assess hippocampal involvement in vivo. It is now accepted that clinical manifestations related to the hippocampus are due not only to focal hippocampal damage, but also to disconnection of the hippocampus from several brain networks. Evidence suggests anatomical and functional subspecialisation of the different hippocampal subfields, resulting in variability between regions in the extent to which damage and repair occur. The hippocampus also has important roles in plasticity and neurogenesis, both of which potentially contribute to functional preservation and restoration. These findings underline the importance of evaluation of the hippocampus not only to improve understanding of the clinical manifestations of multiple sclerosis, but also as a potential future target for treatment.

Original languageEnglish
Pages (from-to)918-926
Number of pages9
JournalThe Lancet Neurology
Volume17
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

Cite this

Rocca, Maria A. ; Barkhof, Frederik ; De Luca, John ; Frisén, Jonas ; Geurts, Jeroen J.G. ; Hulst, Hanneke E. ; MAGNIMS Study Group. / The hippocampus in multiple sclerosis. In: The Lancet Neurology. 2018 ; Vol. 17, No. 10. pp. 918-926.
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abstract = "Some of the clinical manifestations of multiple sclerosis, such as memory impairment and depression, are, at least partly, related to involvement of the hippocampus. Pathological studies have shown extensive demyelination, neuronal damage, and synaptic abnormalities in the hippocampus of patients with multiple sclerosis, and improvements in MRI technology have provided novel ways to assess hippocampal involvement in vivo. It is now accepted that clinical manifestations related to the hippocampus are due not only to focal hippocampal damage, but also to disconnection of the hippocampus from several brain networks. Evidence suggests anatomical and functional subspecialisation of the different hippocampal subfields, resulting in variability between regions in the extent to which damage and repair occur. The hippocampus also has important roles in plasticity and neurogenesis, both of which potentially contribute to functional preservation and restoration. These findings underline the importance of evaluation of the hippocampus not only to improve understanding of the clinical manifestations of multiple sclerosis, but also as a potential future target for treatment.",
author = "Rocca, {Maria A.} and Frederik Barkhof and {De Luca}, John and Jonas Fris{\'e}n and Geurts, {Jeroen J.G.} and Hulst, {Hanneke E.} and {MAGNIMS Study Group} and Olga Ciccarelli and {De Stefano}, Nicola and Christian Enzinger and Massimo Filippi and Frederiksen, {Jette L.} and Claudio Gasperini and Ludwig Kappos and Jacqueline Palace and Rocca, {Maria A.} and Alex Rovira and Jaume Sastre-Garriga and Hugo Vrenken and Yousry, {Tarek A.}",
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Rocca, MA, Barkhof, F, De Luca, J, Frisén, J, Geurts, JJG, Hulst, HE & MAGNIMS Study Group 2018, 'The hippocampus in multiple sclerosis' The Lancet Neurology, vol. 17, no. 10, pp. 918-926. https://doi.org/10.1016/S1474-4422(18)30309-0

The hippocampus in multiple sclerosis. / Rocca, Maria A.; Barkhof, Frederik; De Luca, John; Frisén, Jonas; Geurts, Jeroen J.G.; Hulst, Hanneke E.; MAGNIMS Study Group.

In: The Lancet Neurology, Vol. 17, No. 10, 01.10.2018, p. 918-926.

Research output: Contribution to journalReview articleAcademicpeer-review

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AU - Gasperini, Claudio

AU - Kappos, Ludwig

AU - Palace, Jacqueline

AU - Rocca, Maria A.

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AU - Yousry, Tarek A.

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