De functie van de hypothalame-hypofysaire-bijnier as bij ernstige ziekte

Translated title of the contribution: The hypothalamic-pituitary-adrenal axis in critical illness

A. Beishuizen*, J. J. Spijkstra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The function of the hypothalamic-pituitary-adrenal axis (HPA) plays a central role in the defence against sepsis, trauma or other types of critical illness. Nevertheless, variations in disease severity hamper defining unequivocal criteria for proper function and dysfunction of the axis. Administration of corticosteroids can improve hemodynamic instability and thereby support a diagnosis of 'relative' adrenocortical insufficiency. It is unclear, however, when and how the treatment should be applied, and whether survival is improved.

Original languageDutch
Pages (from-to)65-70
Number of pages6
JournalNederlands Tijdschrift voor Intensive Care
Volume16
Issue numberMAR.
Publication statusPublished - 1 Dec 2001

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