The function of the hypothalamic-pituitary-adrenal axis (HPA) plays a central role in the defence against sepsis, trauma or other types of critical illness. Nevertheless, variations in disease severity hamper defining unequivocal criteria for proper function and dysfunction of the axis. Administration of corticosteroids can improve hemodynamic instability and thereby support a diagnosis of 'relative' adrenocortical insufficiency. It is unclear, however, when and how the treatment should be applied, and whether survival is improved.
|Translated title of the contribution||The hypothalamic-pituitary-adrenal axis in critical illness|
|Number of pages||6|
|Journal||Nederlands Tijdschrift voor Intensive Care|
|Publication status||Published - 1 Dec 2001|