TY - JOUR
T1 - The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure
T2 - Foods and HPA Axis
AU - Rutters, Femke
AU - La Fleur, Susanne
AU - Lemmens, Sofie
AU - Born, Jurriaan
AU - Martens, Mieke
AU - Adam, Tanja
PY - 2012/12
Y1 - 2012/12
N2 - The prevalence of overweight and obesity has increased worldwide to epidemic proportions. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and chronic stress exposure are hypothesized to contribute to obesity development. In this review, we discuss the potential role of the HPA axis for energy balance regulation, with particular attention to energy intake. We present evidence from human and animal studies that highlight the bidirectional relationship between HPA axis functioning and energy intake. Of particular interest is the association between dysregulation of the HPA axis and altered homeostatic and non-homeostatic food intake regulation. Lastly, we discuss a model depicting a role for a hyperactive HPA axis in overeating and the development of obesity, suggesting chronic stress as a major risk factor for excessive weight gain and (visceral) obesity.
AB - The prevalence of overweight and obesity has increased worldwide to epidemic proportions. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and chronic stress exposure are hypothesized to contribute to obesity development. In this review, we discuss the potential role of the HPA axis for energy balance regulation, with particular attention to energy intake. We present evidence from human and animal studies that highlight the bidirectional relationship between HPA axis functioning and energy intake. Of particular interest is the association between dysregulation of the HPA axis and altered homeostatic and non-homeostatic food intake regulation. Lastly, we discuss a model depicting a role for a hyperactive HPA axis in overeating and the development of obesity, suggesting chronic stress as a major risk factor for excessive weight gain and (visceral) obesity.
KW - Energy intake
KW - Homeostatic and non-homeostatic
KW - HPA axis functioning
KW - Hypothalamic-pituitary-adrenal axis
KW - Obesity
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=85010219731&partnerID=8YFLogxK
U2 - 10.1007/s13679-012-0024-9
DO - 10.1007/s13679-012-0024-9
M3 - Review article
AN - SCOPUS:85010219731
VL - 1
SP - 199
EP - 207
JO - Current Obesity Reports
JF - Current Obesity Reports
SN - 2162-4968
IS - 4
ER -