Abstract
Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.
| Original language | English |
|---|---|
| Pages (from-to) | 8-23 |
| Number of pages | 16 |
| Journal | Clinical Immunology |
| Volume | 112 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 2004 |
Cite this
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The immunoregulatory role of CD1d-restricted natural killer T cells in disease. / van der Vliet, Hans J J; Molling, Johan W; von Blomberg, B Mary E; Nishi, Nobusuke; Kölgen, Wendy; van den Eertwegh, Alfons J M; Pinedo, Herbert M; Giaccone, Giuseppe; Scheper, Rik J.
In: Clinical Immunology, Vol. 112, No. 1, 07.2004, p. 8-23.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - The immunoregulatory role of CD1d-restricted natural killer T cells in disease
AU - van der Vliet, Hans J J
AU - Molling, Johan W
AU - von Blomberg, B Mary E
AU - Nishi, Nobusuke
AU - Kölgen, Wendy
AU - van den Eertwegh, Alfons J M
AU - Pinedo, Herbert M
AU - Giaccone, Giuseppe
AU - Scheper, Rik J
PY - 2004/7
Y1 - 2004/7
N2 - Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.
AB - Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.
KW - Adjuvants, Immunologic
KW - Animals
KW - Antigens, CD1/immunology
KW - Antigens, CD1d
KW - Autoimmune Diseases/immunology
KW - Communicable Diseases/immunology
KW - Galactosylceramides/immunology
KW - Graft Survival/immunology
KW - Humans
KW - Hypersensitivity/immunology
KW - Immunotherapy/methods
KW - Killer Cells, Natural/cytology
KW - Mice
KW - Neoplasms/immunology
KW - T-Lymphocytes/cytology
U2 - 10.1016/j.clim.2004.03.003
DO - 10.1016/j.clim.2004.03.003
M3 - Review article
VL - 112
SP - 8
EP - 23
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 1
ER -