The immunoregulatory role of CD1d-restricted natural killer T cells in disease

Hans J J van der Vliet; Johan W Molling; B Mary E von Blomberg; Nobusuke Nishi; Wendy Kölgen; Alfons J M van den Eertwegh; Herbert M Pinedo; Giuseppe Giaccone; Rik J Scheper

doi:10.1016/j.clim.2004.03.003

The immunoregulatory role of CD1d-restricted natural killer T cells in disease

Hans J J van der Vliet, Johan W Molling, B Mary E von Blomberg, Nobusuke Nishi, Wendy Kölgen, Alfons J M van den Eertwegh, Herbert M Pinedo, Giuseppe Giaccone, Rik J Scheper

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.

Original language	English
Pages (from-to)	8-23
Number of pages	16
Journal	Clinical Immunology
Volume	112
Issue number	1
DOIs	https://doi.org/10.1016/j.clim.2004.03.003
Publication status	Published - Jul 2004

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van der Vliet, H. J. J., Molling, J. W., von Blomberg, B. M. E., Nishi, N., Kölgen, W., van den Eertwegh, A. J. M., ... Scheper, R. J. (2004). The immunoregulatory role of CD1d-restricted natural killer T cells in disease. Clinical Immunology, 112(1), 8-23. https://doi.org/10.1016/j.clim.2004.03.003

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abstract = "Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.",

keywords = "Adjuvants, Immunologic, Animals, Antigens, CD1/immunology, Antigens, CD1d, Autoimmune Diseases/immunology, Communicable Diseases/immunology, Galactosylceramides/immunology, Graft Survival/immunology, Humans, Hypersensitivity/immunology, Immunotherapy/methods, Killer Cells, Natural/cytology, Mice, Neoplasms/immunology, T-Lymphocytes/cytology",

author = "{van der Vliet}, {Hans J J} and Molling, {Johan W} and {von Blomberg}, {B Mary E} and Nobusuke Nishi and Wendy K{\"o}lgen and {van den Eertwegh}, {Alfons J M} and Pinedo, {Herbert M} and Giuseppe Giaccone and Scheper, {Rik J}",

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The immunoregulatory role of CD1d-restricted natural killer T cells in disease. / van der Vliet, Hans J J; Molling, Johan W; von Blomberg, B Mary E; Nishi, Nobusuke; Kölgen, Wendy; van den Eertwegh, Alfons J M; Pinedo, Herbert M; Giaccone, Giuseppe; Scheper, Rik J.

In: Clinical Immunology, Vol. 112, No. 1, 07.2004, p. 8-23.

Research output: Contribution to journal › Review article › Academic › peer-review

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AU - Molling, Johan W

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AU - Kölgen, Wendy

AU - van den Eertwegh, Alfons J M

AU - Pinedo, Herbert M

AU - Giaccone, Giuseppe

AU - Scheper, Rik J

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KW - Hypersensitivity/immunology

KW - Immunotherapy/methods

KW - Killer Cells, Natural/cytology

KW - Mice

KW - Neoplasms/immunology

KW - T-Lymphocytes/cytology

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