The immunoregulatory role of CD1d-restricted natural killer T cells in disease

Hans J J van der Vliet, Johan W Molling, B Mary E von Blomberg, Nobusuke Nishi, Wendy Kölgen, Alfons J M van den Eertwegh, Herbert M Pinedo, Giuseppe Giaccone, Rik J Scheper

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.

Original languageEnglish
Pages (from-to)8-23
Number of pages16
JournalClinical Immunology
Volume112
Issue number1
DOIs
Publication statusPublished - Jul 2004

Cite this

van der Vliet, Hans J J ; Molling, Johan W ; von Blomberg, B Mary E ; Nishi, Nobusuke ; Kölgen, Wendy ; van den Eertwegh, Alfons J M ; Pinedo, Herbert M ; Giaccone, Giuseppe ; Scheper, Rik J. / The immunoregulatory role of CD1d-restricted natural killer T cells in disease. In: Clinical Immunology. 2004 ; Vol. 112, No. 1. pp. 8-23.
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abstract = "Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.",
keywords = "Adjuvants, Immunologic, Animals, Antigens, CD1/immunology, Antigens, CD1d, Autoimmune Diseases/immunology, Communicable Diseases/immunology, Galactosylceramides/immunology, Graft Survival/immunology, Humans, Hypersensitivity/immunology, Immunotherapy/methods, Killer Cells, Natural/cytology, Mice, Neoplasms/immunology, T-Lymphocytes/cytology",
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year = "2004",
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The immunoregulatory role of CD1d-restricted natural killer T cells in disease. / van der Vliet, Hans J J; Molling, Johan W; von Blomberg, B Mary E; Nishi, Nobusuke; Kölgen, Wendy; van den Eertwegh, Alfons J M; Pinedo, Herbert M; Giaccone, Giuseppe; Scheper, Rik J.

In: Clinical Immunology, Vol. 112, No. 1, 07.2004, p. 8-23.

Research output: Contribution to journalReview articleAcademicpeer-review

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T1 - The immunoregulatory role of CD1d-restricted natural killer T cells in disease

AU - van der Vliet, Hans J J

AU - Molling, Johan W

AU - von Blomberg, B Mary E

AU - Nishi, Nobusuke

AU - Kölgen, Wendy

AU - van den Eertwegh, Alfons J M

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AU - Giaccone, Giuseppe

AU - Scheper, Rik J

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AB - Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.

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KW - Galactosylceramides/immunology

KW - Graft Survival/immunology

KW - Humans

KW - Hypersensitivity/immunology

KW - Immunotherapy/methods

KW - Killer Cells, Natural/cytology

KW - Mice

KW - Neoplasms/immunology

KW - T-Lymphocytes/cytology

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