The impact of a pulmonary-artery-catheter-based protocol on fluid and catecholamine administration in early sepsis

Carina Bethlehem, Frouwke M Groenwold, Hanneke Buter, W Peter Kingma, Michael A Kuiper, Fellery de Lange, Paul Elbers, Henk Groen, Eric N van Roon, E Christiaan Boerma

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective. The pulmonary artery catheter (PAC) remains topic of debate. Despite abundant data, it is of note that many trials did not incorporate a treatment protocol. Methods. We retrospectively evaluated fluid balances and catecholamine doses in septic patients after the introduction of a PAC-based treatment protocol in comparison to historic controls. Results. 2 × 70 patients were included. The first day the PAC group had a significantly higher positive fluid balance in comparison to controls (6.1 ± 2.6 versus 3.8 ± 2.4 litre, P < 0.001). After 7 days the cumulative fluid balance in the PAC group was significantly lower than in controls (9.4 ± 7.4 versus 13 ± 7.6 litre, P = 0.001). Maximum dose of norepinephrine was significantly higher in the PAC group. Compared to controls this was associated with a significant reduction in ventilator and ICU days. Conclusions. Introduction of a PAC-based treatment protocol in sepsis changed the administration of fluid and vasopressors significantly.

Original languageEnglish
Pages (from-to)161879
JournalCritical care research and practice
Volume2012
DOIs
Publication statusPublished - 2012

Cite this

Bethlehem, C., Groenwold, F. M., Buter, H., Kingma, W. P., Kuiper, M. A., de Lange, F., ... Boerma, E. C. (2012). The impact of a pulmonary-artery-catheter-based protocol on fluid and catecholamine administration in early sepsis. Critical care research and practice, 2012, 161879. https://doi.org/10.1155/2012/161879