The impact of blood glucose levels on stimulated adrenocorticotropin hormone and growth hormone release in healthy subjects

S. Jakobsdottir, J.W.R. Twisk, M.L. Drent

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

P>Objective In studies investigating the influence of glucose levels on the pituitary function the methods used have been variable and mainly focused on the change in function as a reaction to unphysiological low or high blood glucose levels. In the present study the impact of physiological and elevated blood glucose levels on adrenocorticotropin hormone (ACTH) and growth hormone release are investigated. Design The euglycaemic and hyperglycaemic clamp techniques were used to reach stable levels of 4, 8 and 12 mmol/l blood glucose levels. After a stabilization phase of 2 h, a corticotropin releasing hormone (CRH) or a growth hormone releasing hormone (GHRH) stimulation test was performed. Subjects Seven and eight healthy male volunteers, belonging to two groups, participated in this study. Measurements The area under the curve (AUC), peak values and time to peak of ACTH, cortisol and growth hormone were calculated to evaluate the response to the CRH and GHRH stimulation test. Results The peak values of ACTH, cortisol and growth hormone seemed to be the highest during the 4 mmol/l clamp sessions, compared with the 8 and 12 mmol/l clamps, although the differences were not statistically significant when analysed for every subject individually. The AUC and time to peak measurements were comparable during the three clamp procedures. Conclusion The pituitary reaction on CRH and GHRH was not significantly changed by various blood glucose levels
Original languageUndefined/Unknown
Pages (from-to)853-859
JournalClinical Endocrinology
Volume71
Issue number6
DOIs
Publication statusPublished - 2009

Cite this

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title = "The impact of blood glucose levels on stimulated adrenocorticotropin hormone and growth hormone release in healthy subjects",
abstract = "P>Objective In studies investigating the influence of glucose levels on the pituitary function the methods used have been variable and mainly focused on the change in function as a reaction to unphysiological low or high blood glucose levels. In the present study the impact of physiological and elevated blood glucose levels on adrenocorticotropin hormone (ACTH) and growth hormone release are investigated. Design The euglycaemic and hyperglycaemic clamp techniques were used to reach stable levels of 4, 8 and 12 mmol/l blood glucose levels. After a stabilization phase of 2 h, a corticotropin releasing hormone (CRH) or a growth hormone releasing hormone (GHRH) stimulation test was performed. Subjects Seven and eight healthy male volunteers, belonging to two groups, participated in this study. Measurements The area under the curve (AUC), peak values and time to peak of ACTH, cortisol and growth hormone were calculated to evaluate the response to the CRH and GHRH stimulation test. Results The peak values of ACTH, cortisol and growth hormone seemed to be the highest during the 4 mmol/l clamp sessions, compared with the 8 and 12 mmol/l clamps, although the differences were not statistically significant when analysed for every subject individually. The AUC and time to peak measurements were comparable during the three clamp procedures. Conclusion The pituitary reaction on CRH and GHRH was not significantly changed by various blood glucose levels",
author = "S. Jakobsdottir and J.W.R. Twisk and M.L. Drent",
year = "2009",
doi = "10.1111/j.1365-2265.2009.03590.x",
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The impact of blood glucose levels on stimulated adrenocorticotropin hormone and growth hormone release in healthy subjects. / Jakobsdottir, S.; Twisk, J.W.R.; Drent, M.L.

In: Clinical Endocrinology, Vol. 71, No. 6, 2009, p. 853-859.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The impact of blood glucose levels on stimulated adrenocorticotropin hormone and growth hormone release in healthy subjects

AU - Jakobsdottir, S.

AU - Twisk, J.W.R.

AU - Drent, M.L.

PY - 2009

Y1 - 2009

N2 - P>Objective In studies investigating the influence of glucose levels on the pituitary function the methods used have been variable and mainly focused on the change in function as a reaction to unphysiological low or high blood glucose levels. In the present study the impact of physiological and elevated blood glucose levels on adrenocorticotropin hormone (ACTH) and growth hormone release are investigated. Design The euglycaemic and hyperglycaemic clamp techniques were used to reach stable levels of 4, 8 and 12 mmol/l blood glucose levels. After a stabilization phase of 2 h, a corticotropin releasing hormone (CRH) or a growth hormone releasing hormone (GHRH) stimulation test was performed. Subjects Seven and eight healthy male volunteers, belonging to two groups, participated in this study. Measurements The area under the curve (AUC), peak values and time to peak of ACTH, cortisol and growth hormone were calculated to evaluate the response to the CRH and GHRH stimulation test. Results The peak values of ACTH, cortisol and growth hormone seemed to be the highest during the 4 mmol/l clamp sessions, compared with the 8 and 12 mmol/l clamps, although the differences were not statistically significant when analysed for every subject individually. The AUC and time to peak measurements were comparable during the three clamp procedures. Conclusion The pituitary reaction on CRH and GHRH was not significantly changed by various blood glucose levels

AB - P>Objective In studies investigating the influence of glucose levels on the pituitary function the methods used have been variable and mainly focused on the change in function as a reaction to unphysiological low or high blood glucose levels. In the present study the impact of physiological and elevated blood glucose levels on adrenocorticotropin hormone (ACTH) and growth hormone release are investigated. Design The euglycaemic and hyperglycaemic clamp techniques were used to reach stable levels of 4, 8 and 12 mmol/l blood glucose levels. After a stabilization phase of 2 h, a corticotropin releasing hormone (CRH) or a growth hormone releasing hormone (GHRH) stimulation test was performed. Subjects Seven and eight healthy male volunteers, belonging to two groups, participated in this study. Measurements The area under the curve (AUC), peak values and time to peak of ACTH, cortisol and growth hormone were calculated to evaluate the response to the CRH and GHRH stimulation test. Results The peak values of ACTH, cortisol and growth hormone seemed to be the highest during the 4 mmol/l clamp sessions, compared with the 8 and 12 mmol/l clamps, although the differences were not statistically significant when analysed for every subject individually. The AUC and time to peak measurements were comparable during the three clamp procedures. Conclusion The pituitary reaction on CRH and GHRH was not significantly changed by various blood glucose levels

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