The importance of fluence rate in photodynamic therapy: is there a parallel with ionizing radiation dose-rate effects?

Ruth B. Veenhuizen; F. A. Stewart

doi:10.1016/0167-8140(95)01626-R

The importance of fluence rate in photodynamic therapy: is there a parallel with ionizing radiation dose-rate effects?

Ruth B. Veenhuizen, F. A. Stewart^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Several similarities can be found between dose-rate effects in radiotherapy and fluence-rate effects in photodynamic therapy (PDT). At low dose rates repair of sublethal damage can occur, whereas at high dose rates oxygen depletion can decrease the effects of both therapies. The available literature for fluence-rate effects in PDT is discussed here in relation to therapeutic implications.

Original language	English
Pages (from-to)	131-135
Number of pages	5
Journal	Radiotherapy and Oncology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/0167-8140(95)01626-R
Publication status	Published - Nov 1995

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title = "The importance of fluence rate in photodynamic therapy: is there a parallel with ionizing radiation dose-rate effects?",

abstract = "Several similarities can be found between dose-rate effects in radiotherapy and fluence-rate effects in photodynamic therapy (PDT). At low dose rates repair of sublethal damage can occur, whereas at high dose rates oxygen depletion can decrease the effects of both therapies. The available literature for fluence-rate effects in PDT is discussed here in relation to therapeutic implications.",

keywords = "Dose-rate effect, Fluence rate, Ionizing radiation, Photodynamic therapy",

author = "Veenhuizen, {Ruth B.} and Stewart, {F. A.}",

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AU - Stewart, F. A.

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N2 - Several similarities can be found between dose-rate effects in radiotherapy and fluence-rate effects in photodynamic therapy (PDT). At low dose rates repair of sublethal damage can occur, whereas at high dose rates oxygen depletion can decrease the effects of both therapies. The available literature for fluence-rate effects in PDT is discussed here in relation to therapeutic implications.

AB - Several similarities can be found between dose-rate effects in radiotherapy and fluence-rate effects in photodynamic therapy (PDT). At low dose rates repair of sublethal damage can occur, whereas at high dose rates oxygen depletion can decrease the effects of both therapies. The available literature for fluence-rate effects in PDT is discussed here in relation to therapeutic implications.

KW - Dose-rate effect

KW - Fluence rate

KW - Ionizing radiation

KW - Photodynamic therapy

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ER -

The importance of fluence rate in photodynamic therapy: is there a parallel with ionizing radiation dose-rate effects?

Abstract

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