The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay

K A Hartmann, U M Carl, P Sminia, G Lammering, K A Becker, G Schmitt

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We investigated the ischemia-reperfusion-induced tumour growth delay as a function of ischemic time, tumour temperature, and the amount of inspired oxygen during reperfusion. The rhabdomyosarcoma R1H growing on the right flank of male WAG/Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C. Five minutes prior to and 10 min during reperfusion the animals respired air, pure oxygen or carbogen (95% O2, 5% CO2). Comparison of single treatment modalities with untreated controls revealed significant tumour growth delays after clamping times of 4 h at 37 degrees C for air and pure oxygen, but not for carbogen.

Original languageEnglish
Pages (from-to)131-3
Number of pages3
JournalOncology Reports
Volume7
Issue number1
Publication statusPublished - 22 Dec 1999

Cite this

Hartmann, K. A., Carl, U. M., Sminia, P., Lammering, G., Becker, K. A., & Schmitt, G. (1999). The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay. Oncology Reports, 7(1), 131-3.
Hartmann, K A ; Carl, U M ; Sminia, P ; Lammering, G ; Becker, K A ; Schmitt, G. / The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay. In: Oncology Reports. 1999 ; Vol. 7, No. 1. pp. 131-3.
@article{448f00d479d74d02b9ae6e0a25023a95,
title = "The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay",
abstract = "We investigated the ischemia-reperfusion-induced tumour growth delay as a function of ischemic time, tumour temperature, and the amount of inspired oxygen during reperfusion. The rhabdomyosarcoma R1H growing on the right flank of male WAG/Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C. Five minutes prior to and 10 min during reperfusion the animals respired air, pure oxygen or carbogen (95{\%} O2, 5{\%} CO2). Comparison of single treatment modalities with untreated controls revealed significant tumour growth delays after clamping times of 4 h at 37 degrees C for air and pure oxygen, but not for carbogen.",
keywords = "Animals, Carbon Dioxide/pharmacology, Cell Division, Ischemia/pathology, Male, Oxygen/pharmacology, Rats, Rats, Inbred Strains, Reperfusion, Rhabdomyosarcoma/blood supply",
author = "Hartmann, {K A} and Carl, {U M} and P Sminia and G Lammering and Becker, {K A} and G Schmitt",
year = "1999",
month = "12",
day = "22",
language = "English",
volume = "7",
pages = "131--3",
journal = "Oncology Reports",
issn = "1021-335X",
publisher = "Spandidos Publications",
number = "1",

}

Hartmann, KA, Carl, UM, Sminia, P, Lammering, G, Becker, KA & Schmitt, G 1999, 'The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay' Oncology Reports, vol. 7, no. 1, pp. 131-3.

The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay. / Hartmann, K A; Carl, U M; Sminia, P; Lammering, G; Becker, K A; Schmitt, G.

In: Oncology Reports, Vol. 7, No. 1, 22.12.1999, p. 131-3.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay

AU - Hartmann, K A

AU - Carl, U M

AU - Sminia, P

AU - Lammering, G

AU - Becker, K A

AU - Schmitt, G

PY - 1999/12/22

Y1 - 1999/12/22

N2 - We investigated the ischemia-reperfusion-induced tumour growth delay as a function of ischemic time, tumour temperature, and the amount of inspired oxygen during reperfusion. The rhabdomyosarcoma R1H growing on the right flank of male WAG/Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C. Five minutes prior to and 10 min during reperfusion the animals respired air, pure oxygen or carbogen (95% O2, 5% CO2). Comparison of single treatment modalities with untreated controls revealed significant tumour growth delays after clamping times of 4 h at 37 degrees C for air and pure oxygen, but not for carbogen.

AB - We investigated the ischemia-reperfusion-induced tumour growth delay as a function of ischemic time, tumour temperature, and the amount of inspired oxygen during reperfusion. The rhabdomyosarcoma R1H growing on the right flank of male WAG/Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C. Five minutes prior to and 10 min during reperfusion the animals respired air, pure oxygen or carbogen (95% O2, 5% CO2). Comparison of single treatment modalities with untreated controls revealed significant tumour growth delays after clamping times of 4 h at 37 degrees C for air and pure oxygen, but not for carbogen.

KW - Animals

KW - Carbon Dioxide/pharmacology

KW - Cell Division

KW - Ischemia/pathology

KW - Male

KW - Oxygen/pharmacology

KW - Rats

KW - Rats, Inbred Strains

KW - Reperfusion

KW - Rhabdomyosarcoma/blood supply

M3 - Article

VL - 7

SP - 131

EP - 133

JO - Oncology Reports

JF - Oncology Reports

SN - 1021-335X

IS - 1

ER -

Hartmann KA, Carl UM, Sminia P, Lammering G, Becker KA, Schmitt G. The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay. Oncology Reports. 1999 Dec 22;7(1):131-3.