TY - JOUR
T1 - The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study
AU - Bosma, I.
AU - Stam, C.J.
AU - Douw, L.
AU - Bartolomei, F.
AU - Heimans, J.J.
AU - van Dijk, B.W.
AU - Postma, T.J.
AU - Klein, M.
AU - Reijneveld, J.C.
PY - 2008
Y1 - 2008
N2 - Purpose: In the present MEG-study, power
spectral analysis of oscillatory brain activity was used to
compare resting state brain activity in both low-grade glioma
(LGG) patients and healthy controls. We hypothesized
that LGG patients show local as well as diffuse slowing of
resting state brain activity compared to healthy controls
and that particularly global slowing correlates with neurocognitive
dysfunction. Patient and methods Resting state
MEG recordings were obtained from 17 LGG patients and
17 age-, sex-, and education-matched healthy controls.
Relative spectral power was calculated in the delta, theta,
upper and lower alpha, beta, and gamma frequency band. A
battery of standardized neurocognitive tests measuring 6
neurocognitive domains was administered. Results: LGG
patients showed a slowing of the resting state brain activity
when compared to healthy controls. Decrease in relative
power was mainly found in the gamma frequency band in
the bilateral frontocentral MEG regions, whereas an
increase in relative power was found in the theta frequency
band in the left parietal region. An increase of the relative
power in the theta and lower alpha band correlated with
impaired executive functioning, information processing,
and working memory. Conclusion: LGG patients are characterized
by global slowing of their resting state brain
activity and this slowing phenomenon correlates with the
observed neurocognitive deficits.
AB - Purpose: In the present MEG-study, power
spectral analysis of oscillatory brain activity was used to
compare resting state brain activity in both low-grade glioma
(LGG) patients and healthy controls. We hypothesized
that LGG patients show local as well as diffuse slowing of
resting state brain activity compared to healthy controls
and that particularly global slowing correlates with neurocognitive
dysfunction. Patient and methods Resting state
MEG recordings were obtained from 17 LGG patients and
17 age-, sex-, and education-matched healthy controls.
Relative spectral power was calculated in the delta, theta,
upper and lower alpha, beta, and gamma frequency band. A
battery of standardized neurocognitive tests measuring 6
neurocognitive domains was administered. Results: LGG
patients showed a slowing of the resting state brain activity
when compared to healthy controls. Decrease in relative
power was mainly found in the gamma frequency band in
the bilateral frontocentral MEG regions, whereas an
increase in relative power was found in the theta frequency
band in the left parietal region. An increase of the relative
power in the theta and lower alpha band correlated with
impaired executive functioning, information processing,
and working memory. Conclusion: LGG patients are characterized
by global slowing of their resting state brain
activity and this slowing phenomenon correlates with the
observed neurocognitive deficits.
U2 - 10.1007/s11060-008-9535-3
DO - 10.1007/s11060-008-9535-3
M3 - Article
C2 - 18259691
VL - 88
SP - 77
EP - 85
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 1
ER -