The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

Stefan Frantz, Ines Falcao-Pires, Jean Luc Balligand, Johann Bauersachs, Dirk Brutsaert, Michele Ciccarelli, Dana Dawson, Leon J. de Windt, Mauro Giacca, Nazha Hamdani, Denise Hilfiker-Kleiner, Emilio Hirsch, Adelino Leite-Moreira, Manuel Mayr, Thomas Thum, Carlo G. Tocchetti, Jolanda van der Velden, Gilda Varricchi, Stephane Heymans

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a maladaptive role of the immune system. However, several phase III trials failed to show beneficial effects in HF with therapies directed against an immune activation. Preclinical studies today describe positive and negative effects of immune activation in HF. These different effects depend on timing and aetiology of HF. Therefore, herein we give a detailed review on immune mechanisms and their importance for the development of HF with a special focus on commonalities and differences between different forms of cardiomyopathies. The role of the immune system in ischaemic, hypertensive, diabetic, toxic, viral, genetic, peripartum, and autoimmune cardiomyopathy is discussed in depth. Overall, initial damage to the heart leads to disease specific activation of the immune system whereas in the chronic phase of HF overlapping mechanisms occur in different aetiologies.

LanguageEnglish
Pages445-459
Number of pages15
JournalEuropean Journal of Heart Failure
Volume20
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Cite this

Frantz, Stefan ; Falcao-Pires, Ines ; Balligand, Jean Luc ; Bauersachs, Johann ; Brutsaert, Dirk ; Ciccarelli, Michele ; Dawson, Dana ; de Windt, Leon J. ; Giacca, Mauro ; Hamdani, Nazha ; Hilfiker-Kleiner, Denise ; Hirsch, Emilio ; Leite-Moreira, Adelino ; Mayr, Manuel ; Thum, Thomas ; Tocchetti, Carlo G. ; van der Velden, Jolanda ; Varricchi, Gilda ; Heymans, Stephane. / The innate immune system in chronic cardiomyopathy : a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. In: European Journal of Heart Failure. 2018 ; Vol. 20, No. 3. pp. 445-459.
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title = "The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC",
abstract = "Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a maladaptive role of the immune system. However, several phase III trials failed to show beneficial effects in HF with therapies directed against an immune activation. Preclinical studies today describe positive and negative effects of immune activation in HF. These different effects depend on timing and aetiology of HF. Therefore, herein we give a detailed review on immune mechanisms and their importance for the development of HF with a special focus on commonalities and differences between different forms of cardiomyopathies. The role of the immune system in ischaemic, hypertensive, diabetic, toxic, viral, genetic, peripartum, and autoimmune cardiomyopathy is discussed in depth. Overall, initial damage to the heart leads to disease specific activation of the immune system whereas in the chronic phase of HF overlapping mechanisms occur in different aetiologies.",
keywords = "Autoimmune cardiomyopathy, Diabetic cardiomyopathy, Genetic cardiomyopathy, Hypertensive cardiomyopathy, Immune system, Ischaemic cardiomyopathy, Macrophage, Peripartum cardiomyopathy, T-cell, Toxic cardiomyopathy, Viral cardiomyopathy",
author = "Stefan Frantz and Ines Falcao-Pires and Balligand, {Jean Luc} and Johann Bauersachs and Dirk Brutsaert and Michele Ciccarelli and Dana Dawson and {de Windt}, {Leon J.} and Mauro Giacca and Nazha Hamdani and Denise Hilfiker-Kleiner and Emilio Hirsch and Adelino Leite-Moreira and Manuel Mayr and Thomas Thum and Tocchetti, {Carlo G.} and {van der Velden}, Jolanda and Gilda Varricchi and Stephane Heymans",
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doi = "10.1002/ejhf.1138",
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Frantz, S, Falcao-Pires, I, Balligand, JL, Bauersachs, J, Brutsaert, D, Ciccarelli, M, Dawson, D, de Windt, LJ, Giacca, M, Hamdani, N, Hilfiker-Kleiner, D, Hirsch, E, Leite-Moreira, A, Mayr, M, Thum, T, Tocchetti, CG, van der Velden, J, Varricchi, G & Heymans, S 2018, 'The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC', European Journal of Heart Failure, vol. 20, no. 3, pp. 445-459. https://doi.org/10.1002/ejhf.1138

The innate immune system in chronic cardiomyopathy : a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. / Frantz, Stefan; Falcao-Pires, Ines; Balligand, Jean Luc; Bauersachs, Johann; Brutsaert, Dirk; Ciccarelli, Michele; Dawson, Dana; de Windt, Leon J.; Giacca, Mauro; Hamdani, Nazha; Hilfiker-Kleiner, Denise; Hirsch, Emilio; Leite-Moreira, Adelino; Mayr, Manuel; Thum, Thomas; Tocchetti, Carlo G.; van der Velden, Jolanda; Varricchi, Gilda; Heymans, Stephane.

In: European Journal of Heart Failure, Vol. 20, No. 3, 01.03.2018, p. 445-459.

Research output: Contribution to journalReview articleAcademicpeer-review

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T2 - European Journal of Heart Failure

AU - Frantz, Stefan

AU - Falcao-Pires, Ines

AU - Balligand, Jean Luc

AU - Bauersachs, Johann

AU - Brutsaert, Dirk

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AU - Leite-Moreira, Adelino

AU - Mayr, Manuel

AU - Thum, Thomas

AU - Tocchetti, Carlo G.

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AU - Varricchi, Gilda

AU - Heymans, Stephane

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KW - Diabetic cardiomyopathy

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KW - Ischaemic cardiomyopathy

KW - Macrophage

KW - Peripartum cardiomyopathy

KW - T-cell

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KW - Viral cardiomyopathy

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