The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target

A Neil Barclay, Timo K Van den Berg

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47 therefore functions as a "don't-eat-me" signal. Here, we discuss recent structural analysis of CD47-SIRPα interactions and implications of this for the function and evolution of SIRPα and paired receptors in general. Furthermore, we review the proposed roles of CD47-SIRPα interactions in phagocytosis, (auto)immunity, and host defense, as well as its potential significance as a therapeutic target in cancer and inflammation and for improving graft survival in xenotransplantation.

Original languageEnglish
Pages (from-to)25-50
Number of pages26
JournalAnnual Review of Immunology
Volume32
DOIs
Publication statusPublished - 2014

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