The interrelation between FGF23 and glucose metabolism in humans

Stan R. Ursem, Marc G. Vervloet, Rahel M. Büttler, Mariëtte T. Ackermans, Mirjam M. Oosterwerff, Elisabeth M.V. Eekhoff, Paul Lips, Mireille J. Serlie, Susanne E. la Fleur, Annemieke C. Heijboer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aims: Different studies point to a link between glucose metabolism and Fibroblast Growth Factor 23 (FGF23), an osteocyte-derived phosphaturic hormone. We aimed to investigate in humans the effect of (I) a glucose load and (II) a hyperinsulinemic-euglycemic clamp on FGF23 concentrations and conversely (III) the effect of a diet-induced increase in FGF23 concentration on glucose and insulin concentrations. Methods: Plasma cFGF23 concentrations were measured during: I. an oral glucose tolerance test in eight adults with impaired glucose tolerance and vitamin D deficiency and II. a hyperinsulinemic-euglycemic clamp in nine healthy adults. III. Serum glucose and insulin concentrations were measured in nine healthy adults receiving a single-day phosphate-enriched or -restricted diet. Results: I. A glucose load decreased FGF23 and phosphate concentrations. II. The hyperinsulinemic-euglycemic clamp decreased phosphate concentrations, but did not affect FGF23 concentrations. III. Fasting insulin and glucose concentrations remained unchanged after a diet-induced increase in FGF23 concentration. Conclusions: An oral glucose load in vitamin D deficient patients with impaired glucose metabolism decreased FGF23 concentrations, which cannot be attributed to changes in insulin concentration. Thus, bone may react rapidly after glucose loading by alternating FGF23 secretion. A diet-induced increase in FGF23 concentrations did not affect fasting glucose or insulin levels.

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalJournal of Diabetes and its Complications
Issue number9
Publication statusPublished - 1 Sep 2018

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