The macrophage scavenger receptor CD163

Babs O Fabriek, Christine D Dijkstra, Timo K van den Berg

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Mature tissue macrophages form a first line of defense to recognize and eliminate potential pathogens; these specialized cells are capable of phagocytosis, degradation of self and foreign materials, establishment of cell-cell interactions, and the production of inflammatory mediators. Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily members. CD163 is a member of the SRCR family class B and is expressed on most subpopulations of mature tissue macrophages. The best characterized function of CD163, which is essentially a homeostatic one, is related to the binding of Hemoglobin:Haptoglobin complexes. Furthermore, it has been suggested that CD163 positive macrophages or the soluble form of CD163 plays a role in the resolution of inflammation, as they are found in high numbers in inflamed tissue.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalImmunobiology
Volume210
Issue number2-4
DOIs
Publication statusPublished - 2005

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