@article{8d8ba78265354427849235a4e0854a6a,
title = "The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting",
abstract = "Tan et al. identify the E3-ligase MARCH6 as an important regulator of endothelial sprouting angiogenesis, owing to its ability to degrade the cholesterol biosynthetic enzyme SQLE. The study highlights that adequate SQLE levels are a critical determinant of maintaining endothelial junctions and proper sprouting angiogenesis.",
keywords = "adherens junction, angiogenesis, cholesterol metabolism, endothelial barrier, MARCH6, MARCHF6, membrane organization, post-transcriptional regulation, SQLE, VE-cadherin",
author = "Tan, {Josephine Mathilde Elisabeth} and {van der Stoel}, {Miesje Maxime} and {van den Berg}, Marlene and {van Loon}, {Nienke Marlies} and Martina Moeton and Edwin Scholl and {van der Wel}, {Nicole Neeltje} and Igor Kova{\v c}evi{\'c} and Hordijk, {Peter Lodewijk} and Anke Loregger and Stephan Huveneers and Noam Zelcer",
year = "2020",
month = aug,
day = "4",
doi = "10.1016/j.celrep.2020.107944",
language = "English",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",
}