The metastatic potential of rat prostate tumor variant R3327-MatLyLu is correlated with an increased activity of N-acetylglucosaminyl transferase III and V

Ellen W. Easton, Irene Blokland, Albert A. Geldof, B. Ramanath Rao, Dirk H. van den Eijnden

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Enzyme activities of N-acetylglucosaminyltransferase (GlcNAc-Tase) I-V involved in N-linked complex-type carbohydrate synthesis were determined in a non-metastatic hormone-dependent rat prostate tumor (R3327-H) and a related, hormone-independent variant metastasizing to lymph nodes and lungs (R3327-MatLyLu). In the metastasizing variant a significantly increased activity of both GlcNAc-Tase III and GlcNAc-Tase V was observed, whereas the activities of GlcNAc-Tase I and II were essentially unchanged. The increase in activity of GlcNAc-Tase III is particularly noteworthy since it indicates that elevated expression of this enzyme cannot be considered as an exclusive marker of hepatic malignancy.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalFEBS Letters
Volume308
Issue number1
DOIs
Publication statusPublished - 10 Aug 1992

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