The molecular basis for abnormal human lung development

Frederick Groenman, Sharon Unger, Martin Post*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Our understanding of lung development in the past two decades has moved from an anatomical to a histological basis and, most recently, to a molecular basis. Tissue interactions specify tracheal and lung primordia formation, program branching morphogenesis of the airway epithelium and regulate epithelial differentiation. In addition, lung development is influenced by mechanical and humoral factors. The regulatory molecules involved in morphogenetic signaling include growth and transcription factors and extracellular matrix molecules. These morphogenetic signals are responsible for lung patterning and differentiation. We will provide a brief overview of molecular signaling during early respiratory formation, airway branching, pulmonary vascularization and epithelial differentiation. We will then review aberrant morphogenetic signaling in human lung abnormalities, such as tracheoesophageal fistula, congenital diaphragmatic hernia, pulmonary hyperplasia, alveolar capillary dysplasia, congenital cystic adenomatoid malformation and bronchopulmonary dysplasia.

Original languageEnglish
Pages (from-to)164-177
Number of pages14
JournalBiology of the Neonate
Volume87
Issue number3
DOIs
Publication statusPublished - 11 May 2005

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