TY - JOUR
T1 - The path to the standardization of PTH
T2 - Is this a realistic possibility? a position paper of the IFCC C-BM
AU - Cavalier, Etienne
AU - Vasikaran, Samuel
AU - Bhattoa, Harjit P.
AU - Heijboer, Annemieke C.
AU - Makris, Konstantinos
AU - Ulmer, Candice Z.
PY - 2021/4
Y1 - 2021/4
N2 - Parathyroid hormone (PTH) determination is of greatest importance for patients suffering from parathyroid gland disorders and for the follow-up of bone turnover in patients suffering from chronic kidney disease (CKD). Two generations of PTH assays are simultaneously present on the market for PTH quantification. As these assays are not yet standardized, this results in a significant level of confusion in the care of CKD patients. One key objective of the IFCC Committee for Bone Metabolism is to improve this situation. In this position paper, we will highlight the current state of PTH testing and propose a pathway to ultimately overcome issues resulting from PTH assay variability.
AB - Parathyroid hormone (PTH) determination is of greatest importance for patients suffering from parathyroid gland disorders and for the follow-up of bone turnover in patients suffering from chronic kidney disease (CKD). Two generations of PTH assays are simultaneously present on the market for PTH quantification. As these assays are not yet standardized, this results in a significant level of confusion in the care of CKD patients. One key objective of the IFCC Committee for Bone Metabolism is to improve this situation. In this position paper, we will highlight the current state of PTH testing and propose a pathway to ultimately overcome issues resulting from PTH assay variability.
KW - Immunoassays
KW - Parathyroid hormone
KW - Standardization
UR - http://www.scopus.com/inward/record.url?scp=85099168688&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2020.12.022
DO - 10.1016/j.cca.2020.12.022
M3 - Article
C2 - 33412144
AN - SCOPUS:85099168688
VL - 515
SP - 44
EP - 51
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
ER -