TY - JOUR
T1 - The prognostic value of vascular diameter measurements on routine chest computed tomography in patients not referred for cardiovascular indications
AU - Gondrie, Martijn J A
AU - van der Graaf, Yolanda
AU - Jacobs, Peter C
AU - Buckens, Stan C F M
AU - Mali, Willem P. Th. M.
AU - PROVIDI Study Group
PY - 2011/11/16
Y1 - 2011/11/16
N2 - OBJECTIVES: The aim of the study was to investigate whether diameter measurements of the thoracic aorta and the heart can be used as prognostic markers for future cardiovascular disease.METHODS: Following a case-cohort design, a total of 10,410 patients undergoing chest computed tomography were followed up for a mean period of 17 months. The ones with a cardiovascular indication were excluded. Diameter measurements were evaluated with Cox proportional hazard analysis.RESULTS: Five hundred fifteen incident cardiovascular events occurred during follow-up. The heart (hazard ratio [HR], 1.04; 95% confidence interval [CI], 1.03-1.06) and ascending thoracic (HR, 1.002; 95% CI, 1.001-1.004) diameter showed an exponential prognostic effect beyond a threshold diameter of, respectively, 11 and 30 mm; the descending aortic diameter (HR, 1.04; 95% CI, 1.01-1.13) and cardiothoracic ratio (HR, 1.06; 95% CI, 1.04-1.08) showed linear prognostic effects beyond, respectively, 25 and 0.45 mm.CONCLUSION: Intrathoracic diameter measurements can be used as markers to predict cardiovascular events in patients not referred for that disease outcome.
AB - OBJECTIVES: The aim of the study was to investigate whether diameter measurements of the thoracic aorta and the heart can be used as prognostic markers for future cardiovascular disease.METHODS: Following a case-cohort design, a total of 10,410 patients undergoing chest computed tomography were followed up for a mean period of 17 months. The ones with a cardiovascular indication were excluded. Diameter measurements were evaluated with Cox proportional hazard analysis.RESULTS: Five hundred fifteen incident cardiovascular events occurred during follow-up. The heart (hazard ratio [HR], 1.04; 95% confidence interval [CI], 1.03-1.06) and ascending thoracic (HR, 1.002; 95% CI, 1.001-1.004) diameter showed an exponential prognostic effect beyond a threshold diameter of, respectively, 11 and 30 mm; the descending aortic diameter (HR, 1.04; 95% CI, 1.01-1.13) and cardiothoracic ratio (HR, 1.06; 95% CI, 1.04-1.08) showed linear prognostic effects beyond, respectively, 25 and 0.45 mm.CONCLUSION: Intrathoracic diameter measurements can be used as markers to predict cardiovascular events in patients not referred for that disease outcome.
KW - Adult
KW - Aged
KW - Aorta, Thoracic
KW - Cardiovascular Diseases
KW - Case-Control Studies
KW - Chi-Square Distribution
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Predictive Value of Tests
KW - Prognosis
KW - Proportional Hazards Models
KW - Radiography, Thoracic
KW - Regression Analysis
KW - Tomography, X-Ray Computed
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1097/RCT.0b013e318231824a
DO - 10.1097/RCT.0b013e318231824a
M3 - Article
C2 - 22082545
VL - 35
SP - 734
EP - 741
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 6
ER -